GRC3_ASPFU
ID GRC3_ASPFU Reviewed; 841 AA.
AC Q4WID9; A4D9U7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE EC=2.7.1.-;
GN Name=grc3; ORFNames=AFUA_2G02190;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EBA27309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAHF01000008; EBA27309.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001481647.1; XM_001481597.1.
DR AlphaFoldDB; Q4WID9; -.
DR SMR; Q4WID9; -.
DR STRING; 746128.CADAFUBP00001881; -.
DR GeneID; 5076960; -.
DR KEGG; afm:AFUA_2G02190; -.
DR VEuPathDB; FungiDB:Afu2g02190; -.
DR eggNOG; KOG2750; Eukaryota.
DR HOGENOM; CLU_010345_1_2_1; -.
DR InParanoid; Q4WID9; -.
DR OrthoDB; 1217334at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF16575; CLP1_P; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW rRNA processing; Transferase.
FT CHAIN 1..841
FT /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT /id="PRO_0000087588"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..132
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 338..345
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 841 AA; 92574 MW; 28BE249025D2A7E6 CRC64;
MKRKAEKQQA TAPVSAFAAR KARQQQARLL EPEKTAQNEP AVEPPSKRAR RSPEEGAARQ
AANENDRVQT RRSARTKAET LSSAELAEKQ PQESAAAARA QTAERTPPPE KGDADTFDAA
EEEEEEEKEE DILERENGVG VIAVEDDAEG YESPADDVPQ VQNFPLSKTR LNKSNIVSSD
ERTLCVRIKE KMTLVLLGHY DLWVKRGVIS LMGAKLHPSP RLYRVYAPST HSLPVIKCVA
GVDGESEIEV KSCNSGIYRL RHLSPLYQRI WNGKHTAADK LTLKKVSAST KRTFSVLYTS
SDDSWNRHLR PLHLEKQWSS AIRSLSQRGG RLKVLICGPK ASGKSTFSRY LLNHLLSPAP
QTENNHRNTD GVAFLDLDPG QPEFCPMGQV YLAHLRSPFF GPPFTHPSLA ESQDGSIIRS
HHIGAISPKE DPDHYVLAAM DLMDRYRALL ASYPQCPLII NYPGWIFGLG LEVATWLVKS
LGLSDVVYMS EKGPAEVVEP LGHAAQEARV PLTTLPSQPT DFVSRSSAQL RSMQVQSYFH
MSHPSEIHNP QWLDTTMSRT RPLVVDYAGP RQGIRGIMVM GSQISPNLLH EALDGALVGV
VAVESPNAIM GQADAAGFSG SSHGDATQGA EDLSSAASDI DMNDVTDACH GDVAPTSSSS
FESMIIRTPN EDLPYLFVGS GSCNPLDPKA SNCLGLALVR SIDVPSRKLE LITPIPASKL
RDALEQGHGI VLVRGMLDNP SWAISEDYYA ARAAERRHQE LVAKARKETN TRDGQDAAVD
ADTQGMVSAL LKDRIRRASN VPWMTVIEDN SRRHREAAQR KKSLWKLRKK AYPGSESETD
W
