ID   GRC3_ASPNC              Reviewed;         819 AA.
AC   A2QNQ8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=An07g06640;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK39510.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AM270135; CAK39510.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; A2QNQ8; -.
DR   SMR; A2QNQ8; -.
DR   EnsemblFungi; CAK39510; CAK39510; An07g06640.
DR   Proteomes; UP000006706; Chromosome 4L.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..819
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289952"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         333..340
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   819 AA;  90438 MW;  6AD0A39BF395E229 CRC64;
     MKRKAEKAQA AAPVSAFAAR KARQQQAQAT AAAVKPPVAE PVVEPPPKRA RRSLEEPVVP
     VAPEENRVQT RRSSRRKEEQ AKVEKPTPKA RNDQPPKASK KLPEHDTSKA TEDQAPSDEE
     SEEPDVVVGN TGVIGLEPIQ NEEEGYESPA DTAVQVQDFP LSKARLNKNS IVYSDEHRMC
     VRIKEKMSLV MIGHYDLWVK RGVVSLMGAK LHPSSQVYRV YAPSTHSLPV IKCVSGVNGE
     AEVEFKSCHS GIYRLKELSP LYQRIWNGKN TTADKLTLKG TPQSTKRTFS VLYTSADDSF
     KRHLRPLHLE KQWSSAIKSL SQRGGRLKTL ICGPKGSGKS TFSRYLLNHL LSPAPQTETK
     YFNTDGVAFL DLDPGQPEFA PMGQVYLAHL RSPVFGPPFS HPSLDGSRNG TIVRSHHIGA
     TSPKEDPDHY VLAAMDLMDR YRALQASYPQ CPLIINYPGW IFGLGLEVAT WLVRSLGLSD
     VVYMSEKGPT EVVQPLGQAA YQAKIPLTIL PSQPTDFVSR SSAQLRSMQM QSYFHMSRPN
     GINNSLWLEQ PLSRTKPFRV HYSGPQQGIQ GIMVMGTEIH PDLLHEVLDG SIVAVVAVES
     PNAILGQNSG PMFANNANAE TDGDHDVDMQ DSADAVPVIG TSTIESSITR TPNEDLPYLF
     VGAGSSNPLD PKVSHCLGLA LVRSVNVASR QLELVTPITG STLRGVLEQG HSIVLVRGLL
     DNPNWAISED YYAARAAEKR HRELIEKLKK DKGAAAAEDA TLESEKQVLK DRIRRASKVP
     WMTVVEDNSR RQREAAQREK SLWKLRKKAY PGSDSEGDW