ID   GRC3_ASPOR              Reviewed;         831 AA.
AC   Q2U0C4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=AO090011000497;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE64991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007171; BAE64991.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2U0C4; -.
DR   SMR; Q2U0C4; -.
DR   STRING; 510516.Q2U0C4; -.
DR   EnsemblFungi; BAE64991; BAE64991; AO090011000497.
DR   VEuPathDB; FungiDB:AO090011000497; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..831
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289953"
FT   REGION          1..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         335..342
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   831 AA;  91669 MW;  10911A4F9A5BA20E CRC64;
     MKRKAEKQQA AAPAPMSAVA ARKARQQQMQ AAIAVVKPSQ AESVQEPPSK KARRSPEQAA
     PTPPASGEPQ GRTTRSSKRK AESLKVDKLI EKKEKTLSAE YTEQLPVRSS PQEQEDQSSS
     DEESEEQNPI VGENDAGIAP LRGDVDGYES PADTSGPIQE FPLSKTRLNK SNIIYSDEHT
     LCVRIKEKMS LVLLGHYDLW VKRGVVSVMG AKLHPSPRLY RVYAPSTHSL PVIKCVSGVD
     GAAEIEVKSC HSGIYRLRDL SPLYRRIWNG KNTSADKLTL RTSPSSAKRT FSVLYTSADD
     SFKRHLRPLH LEKQWSSAIK SLSQRGGRLK ALICGPKASG KSTFSRYLLN HLLSPAPQTE
     TNYCNTDGVA FLDLDPGQPE FSPMGQVYLA HLRSPVFGPP FSHPSLDSSQ EGTIIRAHHI
     GATSPKEDPD HYVLAAMDLM DRYRALLASY PQCPLIINYP GWIFGLGLEV ATWLVRSLGL
     SDVVYMSEKG PTEVVMPLGQ AAQEAMAPLT ILPSQPTDFV SRSSAQLRSM QMQSYFHMTR
     PTEISNPLWL EKPISRTRPF HVHYAGPKQG IKGVMVMGSQ IDPDLLQEVL DGSIVAVVAV
     ESPQAILGQN DGPGLTINHP AQPIDADVTM DDSTDTPMEG VPLQDPINPF IDANIVRTPT
     ENLPYLFVGS GSSNPLDPKA SRCLGLALVR SIDVSSQRLE LVTPIAGSAI RDALEQSHGI
     VLVRGQLDNP NWAISEDYYA ARAEERRYRE SLEKLKKNEA TTDKEDSIIE PEQQARVSAI
     LRDRIRRASN VPWMTVIEDN SGHQREAAQR EKSLWKLRKK AYPGSDSEGD W