ID   GRC3_ASPTN              Reviewed;         815 AA.
AC   Q0CKU1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=ATEG_05693;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476601; EAU33454.1; -; Genomic_DNA.
DR   RefSeq; XP_001214871.1; XM_001214871.1.
DR   AlphaFoldDB; Q0CKU1; -.
DR   SMR; Q0CKU1; -.
DR   STRING; 341663.Q0CKU1; -.
DR   EnsemblFungi; EAU33454; EAU33454; ATEG_05693.
DR   GeneID; 4321818; -.
DR   VEuPathDB; FungiDB:ATEG_05693; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_2_1; -.
DR   OMA; PLYQRIW; -.
DR   OrthoDB; 1217334at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..815
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289954"
FT   REGION          1..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         326..333
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   815 AA;  89374 MW;  ABE004498765B2E0 CRC64;
     MKRKAEKQQS AAPVSAFAAR KARQQAQIAA TPEPVKPPSA VETTEEPPSK KARTSPEEDT
     PSQSVSPADR VQTRRSSRRK AEPSEIEKTP RRKTKTTPAT PPEHLTDGTV GRESGIQTPV
     EEVSEPEGND VPLDDADRYE SPADTPALVE AFPLSKTRLN KSNIVYSDEH TLCVRIKEKL
     SLVVIGHYDV WVKRGVISLM GAKLHPSPRL YRVYAPSTHS LPVIKCVSGV DGAAEVEIKS
     CHSGIYRLRD LSPLYQRIWN GSNTSADKLT LKNAEPHARR TFSVLYTSTD DSLKRHLRPL
     HLEKQWSSAI KSLSQKGGKL RALICGPKGS GKSTFSRYLL NHLLSPAPQT EPSYCNTDGV
     AFLDLDPGQP EFAPMGQIYL AHLRSPVFGP PFSHPSLEGS QDGTVIRAHH IGASSPKDDP
     DHYVLAATDL MDRYRALLAS YPQCPLIINY PGWIFGLGLE VATWLVRSLG LSDVIYMSEK
     GPAEVVEPLG QAAAAARIPL TTLPSQPTDF VSRSSAQLRS MQMQSYFHMT RPADVSTPLW
     LDQPMSRTRP FKVHYAGPHQ GIRGIMVMGS QIHPDLLHEA LDGSLVGVVA VESPNAILGH
     SEVPGLANGV MGKQPSPAEE GSEDAVMDEA TEMVPTAPLA SIDSGITRSP HEDLPYLFVG
     AGSCNPLDPK ASHCLGLALV RSVNVAARQL ELVTPIAASR IRDALQQGYG IVLVRGQLDN
     PNWALSEEYY AARAAEKRHR RFVDSSRKDK VDDGTDDSAH TSAILKDRIR RASHVPWMTV
     IEDNSRRQRE AAQREKSLWK LRKKAYPGSE SEGDW