ID   3S34_PSETE              Reviewed;          79 AA.
AC   Q9W7J9;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Short neurotoxin 4;
DE            Short=SNTX4;
DE   AltName: Full=Alpha-neurotoxin 4;
DE   Flags: Precursor;
OS   Pseudonaja textilis (Eastern brown snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Acanthophiinae; Pseudonaja.
OX   NCBI_TaxID=8673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Gong N.L., Armugam A., Jeyaseelan K.;
RT   "Cloning and expression of cDNAs encoding short neurotoxins in Pseudonaja
RT   textilis venom.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds with high affinity to muscle nicotinic acetylcholine
CC       receptor (nAChR) and hinders acetylcholine binding to the receptor,
CC       thereby impairing neuromuscular transmission. Causes muscle paralysis,
CC       spasms and increased respiration. {ECO:0000250|UniProtKB:Q9W7K2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Type III alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR   EMBL; AF082978; AAD40970.1; -; mRNA.
DR   AlphaFoldDB; Q9W7J9; -.
DR   SMR; Q9W7J9; -.
DR   Proteomes; UP000472273; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
KW   Reference proteome; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..79
FT                   /note="Short neurotoxin 4"
FT                   /id="PRO_0000035464"
FT   DISULFID        24..41
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        34..59
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        63..71
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   79 AA;  8690 MW;  32607D4A3D89FA1D CRC64;
     MKTLLLTLVM VTIMCLDLGY TLTCYKGYHD TVVCKPHETI CYEYFIPATH GNAILARGCG
     TSCPGGIRPV CCRTDLSNK