ID   GRC3_CANAL              Reviewed;         686 AA.
AC   Q59U11; A0A1D8PT79;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3;
DE            EC=2.7.1.-;
GN   Name=GRC3; OrderedLocusNames=CAALFM_CR06450WA;
GN   ORFNames=CaO19.721, CaO19.8340;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP017630; AOW31344.1; -; Genomic_DNA.
DR   RefSeq; XP_713081.2; XM_707988.2.
DR   AlphaFoldDB; Q59U11; -.
DR   SMR; Q59U11; -.
DR   STRING; 237561.Q59U11; -.
DR   GeneID; 3645279; -.
DR   KEGG; cal:CAALFM_CR06450WA; -.
DR   CGD; CAL0000182248; orf19.8340.
DR   VEuPathDB; FungiDB:CR_06450W_A; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_1_1; -.
DR   InParanoid; Q59U11; -.
DR   OrthoDB; 1217334at2759; -.
DR   PRO; PR:Q59U11; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..686
FT                   /note="Polynucleotide 5'-hydroxyl-kinase GRC3"
FT                   /id="PRO_0000087589"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         265..272
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   686 AA;  77356 MW;  C3C9F42E2ECC1579 CRC64;
     MSAFAALKNN PFGESIFNNT SNGDNHSRDD VEEDEVVQYI ANSSDEDDDD DNDDNDNDQG
     NEDNNLFPLE ISAPVDTSIS STPAPILNSR ITQSNYTPNE SNLKFSDNHV TITLNPSEYI
     IISGQCNLKI IKGSIKINQC HCLTSEDNKS YNIIALQSQS LPIISHYTTP EMEEDGVTSV
     SIIQLENSFS GIENISQIEP AFKNLISGQP NVEEPSLFKN YSFDIVLTET NGGYGLDINS
     YWINELNLLK SNKDDPTPKI IMIIGNKNTG KSTFCKSLIN ELLLTNPNRP VSYLEIDPGQ
     SEYSTPCALS LSEIVQAQFG LAALPHKNNN IVKSRVEHYF GFTSAVNAPT RYVEIIEELF
     NHHQTKFSQR NHLIINTPGW VKGYGKELLN QITKIINPDK LILLSNNLNQ EYPDNANILQ
     DLTYQSLSII PGVYQLSKYS APQIRTINKL LYFHQTTTTG TFNFNDHLLD SSPLKISYAC
     GNSPNNPGIY STTIINHNID NEFSHRDLCS LVEVSIYGIY SIKSNGNTKF DEMSCFRRDD
     GNSPFYLNPD DFDNLLSNET ITSKFIGLIM VHSINPNDHY MNIYAPDIII NRLRKVLSTN
     SNQTNDYKLI MIRGEGDIPN CEMLYPEFIN KKIDYLKSIK KRKAATTSRK LVDLKLPYIS
     FETKSKVGGI WKVRKNIKRR GHHQKG