ID   GRC3_CANGA              Reviewed;         630 AA.
AC   Q6FW56;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3;
DE            EC=2.7.1.-;
GN   Name=GRC3; OrderedLocusNames=CAGL0D02816g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR380950; CAG58449.1; -; Genomic_DNA.
DR   RefSeq; XP_445538.1; XM_445538.1.
DR   AlphaFoldDB; Q6FW56; -.
DR   SMR; Q6FW56; -.
DR   STRING; 5478.XP_445538.1; -.
DR   EnsemblFungi; CAG58449; CAG58449; CAGL0D02816g.
DR   GeneID; 2887173; -.
DR   KEGG; cgr:CAGL0D02816g; -.
DR   CGD; CAL0128421; CAGL0D02816g.
DR   VEuPathDB; FungiDB:CAGL0D02816g; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_1_1; -.
DR   InParanoid; Q6FW56; -.
DR   OMA; EHVWKVR; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0090730; C:Las1 complex; IEA:EnsemblFungi.
DR   GO; GO:0030874; C:nucleolar chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   GO; GO:0006363; P:termination of RNA polymerase I transcription; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..630
FT                   /note="Polynucleotide 5'-hydroxyl-kinase GRC3"
FT                   /id="PRO_0000087590"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         247..254
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   630 AA;  71688 MW;  E896A8BD82CDC013 CRC64;
     MAETDLNALA YKDSDSTDTS SSSSSDEEYQ AEVKVSNQNE KQVDYDSDTD LNTDNKVSSV
     DAYKPCVGEN LIIRDSNIII LLRAKEKLCL SGLFDLKIEK GGLLYNDIHF NASSKTYHYW
     HPLSNSIPEI KSSFYAGFED VDISAFYAAY DISPNNDYET VLKISNHKSK SLIDGEILMP
     SLKSLWITKE DFLQKNGYTN FSFDIIMPAT LQEITTLNIS KSWTNCLQKL KFINQNSIHD
     TRIMVIGGKN SGKSTFLRSL VEKVLYSHDI SDKSVSEMLY LDLDPGQPEF SHPDCISMTR
     LTSNDMNFGQ SFGQASPEVL KQYYIGSPSP QEYPTRYLNM VNKLITEFED TMFAGISCIN
     LPGWVKGFGL NILQKVLEIY KPTDIVYLES PSTVRHFSEL RIPKSFSSTM MTEYSPRSYR
     IPAEFSNAAI NNSPEIKFAP SDIRTYKLLC LFHRSDTSNV PTFDFRPLIA KSPKKISYGR
     AGIHTIIINI EFALVPSHEL IQALEGTIVA IYHEENTDDE HDSSSDIRVL SNDDLETAKF
     ITLGLVHSVD EERKYFNIYV PENMVATLKN LGNRFMIERL STETPFCELS PPNKVLKTDQ
     TSPFISFKTR KKYEHVWKIR KNIKRKGHHL