ID   GRC3_DEBHA              Reviewed;         680 AA.
AC   Q6BQV7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3;
DE            EC=2.7.1.-;
GN   Name=GRC3; OrderedLocusNames=DEHA2E01892g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382137; CAG87624.2; -; Genomic_DNA.
DR   RefSeq; XP_459413.2; XM_459413.1.
DR   AlphaFoldDB; Q6BQV7; -.
DR   SMR; Q6BQV7; -.
DR   STRING; 4959.XP_459413.2; -.
DR   EnsemblFungi; CAG87624; CAG87624; DEHA2E01892g.
DR   GeneID; 2902894; -.
DR   KEGG; dha:DEHA2E01892g; -.
DR   VEuPathDB; FungiDB:DEHA2E01892g; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_1_1; -.
DR   InParanoid; Q6BQV7; -.
DR   OMA; PNIAVEC; -.
DR   OrthoDB; 1217334at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..680
FT                   /note="Polynucleotide 5'-hydroxyl-kinase GRC3"
FT                   /id="PRO_0000087592"
FT   REGION          38..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         268..275
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   680 AA;  77674 MW;  DCEFBD7E960628D0 CRC64;
     MSAYAALQKM SGASSILYGI NGESDNDESG TIGYLRNSSD EEVEAEEAEV PTTSTMAPTP
     NIIRTPSIVP KINSFICESN FIPNDDNFIV FHDHIIIGLK ANEYILINGQ SKMTIQRGAI
     LINTGHYMFA HPNNCIPIIA SQSQSLPIIS STQVVDRSGI KDSKTDENMH LFSSNYKSII
     KLENLYTGLE KIGTYHPPFK RLFYSHAVIE DEDLTEYERL FKTYSFEIIL RDRGCIGISI
     EKLWLNQIQL LISDIHEDLI PKTIMIIGNK NSGKSTLSKT LLNSLILANQ NTVSYLDLDP
     GQSEFSMPYC LSLTNHSKPI IGMNVPKVSG DEDSVSHYYG FTTPQSQPSQ YVSIIKALFR
     EYDQVYRPRG HHLIINTPGW IKGYGKELLN ELTAFINPNQ LILLSNNTDN DNMDNSDNLS
     GLTFQNSRCF QGIYQTSKYS PFQLRMYNKL SYFHQVDTLK FDFNSHILLR SPLKLSYETV
     NSSKDFKGIN MVSVLNYDTG LNFELNDLLS MIDTSIMGLY LIDHEYYSSL KASLKKSEDC
     DYLPQYLNST DYVNLINYSS SNNIFMGLCM VHSINTKDEF FNIYLPGHNQ HRLTEMITKR
     DYKMLLVKGD GDIPSPDLLM FDMLLKQQED LKRLNKKRKK NPNVDDKDVL KIPYVTFENK
     NKIGGIWKTR RNVMRRSHQR