ID   GRC3_EMENI              Reviewed;         816 AA.
AC   Q5B4D1; C8V7U0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=AN4599;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AACD01000079; EAA60401.1; -; Genomic_DNA.
DR   EMBL; BN001303; CBF77175.1; -; Genomic_DNA.
DR   RefSeq; XP_662203.1; XM_657111.1.
DR   AlphaFoldDB; Q5B4D1; -.
DR   SMR; Q5B4D1; -.
DR   STRING; 162425.CADANIAP00005837; -.
DR   EnsemblFungi; CBF77175; CBF77175; ANIA_04599.
DR   EnsemblFungi; EAA60401; EAA60401; AN4599.2.
DR   GeneID; 2872397; -.
DR   KEGG; ani:AN4599.2; -.
DR   VEuPathDB; FungiDB:AN4599; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_2_1; -.
DR   InParanoid; Q5B4D1; -.
DR   OMA; PLYQRIW; -.
DR   OrthoDB; 1217334at2759; -.
DR   Proteomes; UP000000560; Chromosome III.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..816
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289955"
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         332..339
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   816 AA;  89980 MW;  99BE1D555A1EE825 CRC64;
     MMKRKADRQT AAAAPVSAFA ARKARLQQTQ TQVQTVVASE KTTHTDVAAE PPSKRPRRSL
     QESQAQSTSE EDTKRTSKRS AAKTEKVQRV DSGTITRTRE TRMKDSEIEV EDLEKERSSN
     EESEGEDAVE ENAAGVVAVP AAEDGYESPA DNTMTVVFPL SKIRLNKNNI VYSDEDTLCV
     RIQEKLSIVL IGQYDLWVKR GVVSVMGAKL HPSPRVYRVY APSTHSLPVI KCVTGVNGAA
     EVEFKSCHSG ITRLRDLSPL YQRLWNSGNT PADKLSLKAV GQDARRTFSV LHTSADDPLK
     RHLRPLHLEK QWSAAIKVLS QRAGRLQVLI CGPKASGKST FGRYLLNHLL SPAPQPELNY
     TNTDGVAFLD LDPGQPEFLP MGQVYLAHLR SPVFGPPFTH PSLNNEREGT IIRAHHIGAT
     SPKEDPDHYV LAAANLMEQY RTLLATYPQC PLIINYPGWI FGLGLEVATY LIQSLGLSDV
     VYMSEKGPTE VVEPLSQAAS LARVSLTILP SQPTEFVSRS SAQLRSMQMQ SYFHMAQPAG
     VSHPTWLENP VSKNRPFRVR YAGENRGVHG VMTLDSQIIP DLLCESLEGA LVGVVAIESP
     NALPIPSSNA PPANEEEATS NADDDVDMEN ETEHNRNATI SHLTTLTIST KESLPYITSG
     PGTSTPLHPS SSSMLGLALI RSINPDTQTL DLVTPIPSTR LIQSLERGHA LVLVRGVLDN
     PNWAVAEEYY AARAEERRVR RGIRGRKEAG VGEQGDESVE QRLLGLLKER IRRAKDVPFM
     TVVEDHGRRK QEEAAQRALW KLRKKAGIES EDEVGY