GRC3_GIBZE
ID GRC3_GIBZE Reviewed; 720 AA.
AC Q4IR18; A0A0E0RLX5; I1RA23; V6QUY7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3;
DE EC=2.7.1.-;
GN Name=GRC3; ORFNames=FGRRES_00340, FGSG_00340;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000305}.
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DR EMBL; DS231663; ESU05507.1; -; Genomic_DNA.
DR EMBL; HG970332; CEF72250.1; -; Genomic_DNA.
DR RefSeq; XP_011315992.1; XM_011317690.1.
DR AlphaFoldDB; Q4IR18; -.
DR SMR; Q4IR18; -.
DR STRING; 5518.FGSG_00340P0; -.
DR EnsemblFungi; ESU05507; ESU05507; FGSG_00340.
DR GeneID; 23547832; -.
DR KEGG; fgr:FGSG_00340; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G00895; -.
DR eggNOG; KOG2750; Eukaryota.
DR HOGENOM; CLU_010345_1_0_1; -.
DR InParanoid; Q4IR18; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF16575; CLP1_P; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW rRNA processing; Transferase.
FT CHAIN 1..720
FT /note="Polynucleotide 5'-hydroxyl-kinase GRC3"
FT /id="PRO_0000087593"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 285..292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 720 AA; 79096 MW; A689BD10840BF6F9 CRC64;
MSSNKKRRID EKPMSALSAL QARRREAAAS PVQTTQTGSE SDEKSVTTSV NPYQLLRKDS
SQSTAPKTPK KNVVKDQYLP RGAESPASRS RGVVIASGNT DTLNPELAGA SQKVVREYSS
FRLSKQNHRV KTGGVVELNL SNSERFLVLG SFGIRVIQGE VSLAGATLYP SETIEWVHAP
HCHAVPMLRT IDETILELHP DRNARGIRQL GRLSPLFRKI WNESPETNSS KTSKESTFEI
IYTSEDAPKK CIIQKLVSPP EWNKKLSSLV ATSRKKPSLS TLICGPKSAG KSTFSRLFLN
GLLTDRSQKQ GARSVVILDL DPGQPEYAPP GTLSLVFVTK PNLGTPFTHP SLKNSAFTVV
RSHSMASATP APNPDLYLAC ATDLFDTYSK HYSGAPLIVN TPGWIQGTGL DLLSSLIEKI
KPQEVLYMSE AGPDEAVNAL RAATKLMFTE LPSQPSEFTS RTAAHLRAMQ TMSYFHLQNT
ALKTSNLLDT STRLKWDASP LSSRAPLLVQ YSSSKRGVLG LLSYDYQCSP ELLADTVNGL
VLAAVEIEDR KAFSNFPQEV APPPLVSTSP ENIPFIPNYD DVALDPRYSR TIGLVLLRGI
DTKSETLQLV TPIPLEEFRS IKSQGRSIVL LHGKFDTPNW AYTEELYERA GTEEGNDMVL
EVTEEDTEDD QSGVEPEGAD GVSDLTEVPW VEVLKGSQRR PVGSQVWRPL RHLGRNNTGD
