ID   GRC3_NEOFI              Reviewed;         835 AA.
AC   A1CYR9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=NFIA_034570;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS027686; EAW23889.1; -; Genomic_DNA.
DR   RefSeq; XP_001265786.1; XM_001265785.1.
DR   AlphaFoldDB; A1CYR9; -.
DR   SMR; A1CYR9; -.
DR   STRING; 36630.CADNFIAP00003206; -.
DR   PRIDE; A1CYR9; -.
DR   EnsemblFungi; EAW23889; EAW23889; NFIA_034570.
DR   GeneID; 4592867; -.
DR   KEGG; nfi:NFIA_034570; -.
DR   VEuPathDB; FungiDB:NFIA_034570; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_2_1; -.
DR   OMA; PLYQRIW; -.
DR   OrthoDB; 1217334at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..835
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289956"
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..623
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..773
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         332..339
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   835 AA;  91733 MW;  9416A04702C26751 CRC64;
     MKRKAEKQQA TAPVSAFAAR KARQQQAQLV EPEKTAQNEP AVEPPSKRAR WSPEEGAARQ
     AANGNDRVQT RRSTRRKAET LSSELAEKQP QRSAAAARAQ IAERTPAPEK GDAETSDAAE
     EEEEDILERE NGVGVIAAED DAEGYESPAD DVPQVQNFPL SKTRLNKSNI VFSDERTLCV
     RIKEKMTLVL LGHYDLWVKR GVISLMGAKL HPSPRLYRVY APSTHSLPVI KCVAGVDGEA
     EIEVKSCNSG IYRLRHLSPL YQRIWNGKNT AADKLTLKKA SASTKRTFSV LYTSSDDSWN
     RHLRPLHLEK QWSSAIRSLS QRGGRLKVLI CGPKASGKST FSRYLLNHLL SPAPQTENNH
     RNTDGVAFLD LDPGQPEFSP MGQVYLAHLR SPFFGPPFTH PSLAESQDGS IIRSHHIGVT
     SPKEDPDHYV LAAMDLMDRY RALLASYPQC PLIINYPGWI FGLGLEVATW LVKSLGLSDV
     VYMSEKGPAE VVEPLGHAAQ EARVPLTTLP SQPTDFVSRS SAQLRSMQVQ SYFHMSHPSE
     IHNPQWLDTT MSRSRPLVVD YAGPRQGIRG IMVMGSQISP DLLHEALDGA LVGVVAVESP
     NAIMGQADTA GFSGSSQRDA TQGAEDLSGA ASDVDMNDVT DASHGDVAPT SSSSVESMIT
     RTPNEDLPYL FVGSGSCNPL DPKASNCLGL ALVRSIDVPS RKLELITPIP GSKLRDALEQ
     GHGIVLVRGM LDNPSWAISE DYYAARAAEK HHQELVAKAR KETDTRDGRD AAGDADTQGM
     VSALLRDRIR RASNVPWMTV IEDNSRRHRE AAQREKSLWK LRKKAYPGSE SETDW