ID   GRC3_YARLI              Reviewed;         599 AA.
AC   Q6C5P9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3;
DE            EC=2.7.1.-;
GN   Name=GRC3; OrderedLocusNames=YALI0E16258g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR382131; CAG79606.1; -; Genomic_DNA.
DR   RefSeq; XP_504013.1; XM_504013.1.
DR   AlphaFoldDB; Q6C5P9; -.
DR   SMR; Q6C5P9; -.
DR   STRING; 4952.CAG79606; -.
DR   PRIDE; Q6C5P9; -.
DR   EnsemblFungi; CAG79606; CAG79606; YALI0_E16258g.
DR   GeneID; 2911583; -.
DR   KEGG; yli:YALI0E16258g; -.
DR   VEuPathDB; FungiDB:YALI0_E16258g; -.
DR   HOGENOM; CLU_010345_1_2_1; -.
DR   InParanoid; Q6C5P9; -.
DR   OMA; PLYQRIW; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..599
FT                   /note="Polynucleotide 5'-hydroxyl-kinase GRC3"
FT                   /id="PRO_0000087596"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         254..261
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   599 AA;  64810 MW;  0066774996DAC1AE CRC64;
     MTKRKSALSA LKPTKKQVIS SEDSDPEVVV VTNPPLDSPD AEESFISITE EDEAVRQLST
     FDFSAKNTKV VRDETRGRSR VFHGMKFKET IVLRGAYVVT VWSGVIHING ALVNINSPVD
     IPVFAPASHA LPQIEAAAGA PETRESGDED VMEALHQLEG SSVIVEIAAM PRRSENPLIT
     VSNFGKMSSG NIVPFVRQLW HCSEDDGSNY SRIYNTASVV TKSQAAVIPG IYDEWAEVCD
     DIRRLKHSST MVVGSQNTGK STFCKYLSAF MTTKKTGTSV AFVDLDPSNC EFTAPGQVSV
     TVIGAGHLSP YSILGPSFTH VTAPTYSRFV GYNNPKDDTR GYIEACKAVI DFAKGLKLPL
     VFNTCGWVRA AGHDLLRQLI DHVKPSDVVF TRDPGVDADQ ARLAESVKAR SHVLDAPDAE
     PPRFTGAEQH SLQTVTYLHG GNLASHLSDL PALEVGLESV YVGILDSEGV DLADVALSTN
     STLLAVMTMD KKTVKHAEIT PDGLQYLPNF DIPQGECLGQ AMVQFAGASV RLHTPVSASL
     LNAQLAADKA IVLVRGRIPL PVYELWDSRK GGEQAYVSFD VNSGVGSEAW VARRGLKRK