GRCA_ECOSM
ID GRCA_ECOSM Reviewed; 127 AA.
AC B1LP92;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Autonomous glycyl radical cofactor {ECO:0000255|HAMAP-Rule:MF_00806};
GN Name=grcA {ECO:0000255|HAMAP-Rule:MF_00806};
GN OrderedLocusNames=EcSMS35_2732;
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC;
RX PubMed=18708504; DOI=10.1128/jb.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- FUNCTION: Acts as a radical domain for damaged PFL and possibly other
CC radical proteins. {ECO:0000255|HAMAP-Rule:MF_00806}.
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DR EMBL; CP000970; ACB16563.1; -; Genomic_DNA.
DR RefSeq; WP_000627804.1; NC_010498.1.
DR AlphaFoldDB; B1LP92; -.
DR SMR; B1LP92; -.
DR EnsemblBacteria; ACB16563; ACB16563; EcSMS35_2732.
DR GeneID; 60903721; -.
DR GeneID; 67416959; -.
DR KEGG; ecm:EcSMS35_2732; -.
DR HOGENOM; CLU_133780_0_0_6; -.
DR OMA; LGQFEYR; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR HAMAP; MF_00806; GrcA; 1.
DR InterPro; IPR019777; Form_AcTrfase_GR_CS.
DR InterPro; IPR001150; Gly_radical.
DR InterPro; IPR011140; Glycyl_radical_cofactor_GrcA.
DR Pfam; PF01228; Gly_radical; 1.
DR PIRSF; PIRSF000378; Gly_radicl_yfiD; 1.
DR TIGRFAMs; TIGR04365; spare_glycyl; 1.
DR PROSITE; PS00850; GLY_RADICAL_1; 1.
DR PROSITE; PS51149; GLY_RADICAL_2; 1.
PE 3: Inferred from homology;
KW Acetylation; Organic radical.
FT CHAIN 1..127
FT /note="Autonomous glycyl radical cofactor"
FT /id="PRO_1000133988"
FT DOMAIN 5..127
FT /note="Glycine radical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT MOD_RES 48
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT MOD_RES 88
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT MOD_RES 92
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT MOD_RES 102
FT /note="Glycine radical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
SQ SEQUENCE 127 AA; 14268 MW; 6BB8F8F88C8A5E21 CRC64;
MITGIQITKA ANDDLLNSFW LLDSEKGEAR CIVAKAGFAE DEVVAVSKLG DIEYREVPVE
VKPEVRVEGG QHLNVNVLRR ETLEDAVKHP EKYPQLTIRV SGYAVRFNSL TPEQQRDVIA
RTFTESL