ID   GRCA_VIBC3              Reviewed;         125 AA.
AC   A5F5R7; C3M484;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Autonomous glycyl radical cofactor {ECO:0000255|HAMAP-Rule:MF_00806};
GN   Name=grcA {ECO:0000255|HAMAP-Rule:MF_00806};
GN   OrderedLocusNames=VC0395_A1940, VC395_2476;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Acts as a radical domain for damaged PFL and possibly other
CC       radical proteins. {ECO:0000255|HAMAP-Rule:MF_00806}.
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DR   EMBL; CP000627; ABQ20661.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP10466.1; -; Genomic_DNA.
DR   RefSeq; WP_000614136.1; NZ_JAACZH010000008.1.
DR   AlphaFoldDB; A5F5R7; -.
DR   SMR; A5F5R7; -.
DR   STRING; 345073.VC395_2476; -.
DR   EnsemblBacteria; ABQ20661; ABQ20661; VC0395_A1940.
DR   GeneID; 57740971; -.
DR   GeneID; 57990753; -.
DR   GeneID; 66939802; -.
DR   KEGG; vco:VC0395_A1940; -.
DR   KEGG; vcr:VC395_2476; -.
DR   PATRIC; fig|345073.21.peg.2380; -.
DR   eggNOG; COG3445; Bacteria.
DR   HOGENOM; CLU_133780_0_0_6; -.
DR   OMA; LGQFEYR; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   HAMAP; MF_00806; GrcA; 1.
DR   InterPro; IPR019777; Form_AcTrfase_GR_CS.
DR   InterPro; IPR001150; Gly_radical.
DR   InterPro; IPR011140; Glycyl_radical_cofactor_GrcA.
DR   Pfam; PF01228; Gly_radical; 1.
DR   PIRSF; PIRSF000378; Gly_radicl_yfiD; 1.
DR   TIGRFAMs; TIGR04365; spare_glycyl; 1.
DR   PROSITE; PS00850; GLY_RADICAL_1; 1.
DR   PROSITE; PS51149; GLY_RADICAL_2; 1.
PE   3: Inferred from homology;
KW   Organic radical.
FT   CHAIN           1..125
FT                   /note="Autonomous glycyl radical cofactor"
FT                   /id="PRO_1000083738"
FT   DOMAIN          5..125
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT   MOD_RES         100
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
SQ   SEQUENCE   125 AA;  13910 MW;  9E1B491FE0D9C814 CRC64;
     MIQGIQITKA ANDDLLNSIW LLDSEKNEAR CVAALKGFEA DQVVSINDLG QFESREVAIE
     AAPRIEGGQH LNVNVLKRET LEDAVAHPEK YPQLTIRVSG YAVRFNSLTA EQQRDVIART
     FTESL