ID   GRCA_VIBCH              Reviewed;         125 AA.
AC   Q9KPK6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Autonomous glycyl radical cofactor {ECO:0000255|HAMAP-Rule:MF_00806};
GN   Name=grcA {ECO:0000255|HAMAP-Rule:MF_00806}; OrderedLocusNames=VC_2361;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Acts as a radical domain for damaged PFL and possibly other
CC       radical proteins. {ECO:0000255|HAMAP-Rule:MF_00806}.
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DR   EMBL; AE003852; AAF95504.1; -; Genomic_DNA.
DR   PIR; E82086; E82086.
DR   RefSeq; NP_231991.1; NC_002505.1.
DR   RefSeq; WP_000614136.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KPK6; -.
DR   SMR; Q9KPK6; -.
DR   STRING; 243277.VC_2361; -.
DR   DNASU; 2613030; -.
DR   EnsemblBacteria; AAF95504; AAF95504; VC_2361.
DR   GeneID; 57740971; -.
DR   GeneID; 57990753; -.
DR   GeneID; 66939802; -.
DR   KEGG; vch:VC_2361; -.
DR   PATRIC; fig|243277.26.peg.2248; -.
DR   eggNOG; COG3445; Bacteria.
DR   HOGENOM; CLU_133780_0_0_6; -.
DR   OMA; LGQFEYR; -.
DR   BioCyc; VCHO:VC2361-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008861; F:formate C-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006567; P:threonine catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00806; GrcA; 1.
DR   InterPro; IPR019777; Form_AcTrfase_GR_CS.
DR   InterPro; IPR001150; Gly_radical.
DR   InterPro; IPR011140; Glycyl_radical_cofactor_GrcA.
DR   Pfam; PF01228; Gly_radical; 1.
DR   PIRSF; PIRSF000378; Gly_radicl_yfiD; 1.
DR   TIGRFAMs; TIGR04365; spare_glycyl; 1.
DR   PROSITE; PS00850; GLY_RADICAL_1; 1.
DR   PROSITE; PS51149; GLY_RADICAL_2; 1.
PE   3: Inferred from homology;
KW   Organic radical; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Autonomous glycyl radical cofactor"
FT                   /id="PRO_0000166711"
FT   DOMAIN          5..125
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
FT   MOD_RES         100
FT                   /note="Glycine radical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00806"
SQ   SEQUENCE   125 AA;  13910 MW;  9E1B491FE0D9C814 CRC64;
     MIQGIQITKA ANDDLLNSIW LLDSEKNEAR CVAALKGFEA DQVVSINDLG QFESREVAIE
     AAPRIEGGQH LNVNVLKRET LEDAVAHPEK YPQLTIRVSG YAVRFNSLTA EQQRDVIART
     FTESL