GRCR1_DROME
ID GRCR1_DROME Reviewed; 454 AA.
AC Q9VNL4; Q8SZ66;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Glutaredoxin domain-containing cysteine-rich protein CG31559;
GN ORFNames=CG31559;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GRXCR1 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF51916.2; -; Genomic_DNA.
DR EMBL; AY071086; AAL48708.1; -; mRNA.
DR RefSeq; NP_731045.1; NM_169127.3.
DR AlphaFoldDB; Q9VNL4; -.
DR SMR; Q9VNL4; -.
DR BioGRID; 65953; 4.
DR IntAct; Q9VNL4; 6.
DR STRING; 7227.FBpp0078265; -.
DR PaxDb; Q9VNL4; -.
DR DNASU; 40749; -.
DR EnsemblMetazoa; FBtr0078616; FBpp0078265; FBgn0051559.
DR GeneID; 40749; -.
DR KEGG; dme:Dmel_CG31559; -.
DR UCSC; CG31559-RA; d. melanogaster.
DR FlyBase; FBgn0051559; CG31559.
DR VEuPathDB; VectorBase:FBgn0051559; -.
DR eggNOG; KOG2824; Eukaryota.
DR GeneTree; ENSGT00940000171068; -.
DR HOGENOM; CLU_661017_0_0_1; -.
DR InParanoid; Q9VNL4; -.
DR OMA; INEHENF; -.
DR OrthoDB; 686496at2759; -.
DR PhylomeDB; Q9VNL4; -.
DR BioGRID-ORCS; 40749; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40749; -.
DR PRO; PR:Q9VNL4; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051559; Expressed in embryonic epidermis (Drosophila) and 11 other tissues.
DR Genevisible; Q9VNL4; DM.
DR GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..454
FT /note="Glutaredoxin domain-containing cysteine-rich protein
FT CG31559"
FT /id="PRO_0000349193"
FT DOMAIN 295..400
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT REGION 30..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 50164 MW; F89BEE6F237904A2 CRC64;
MVLATPPVSK GGNAGGLFMD QYQQYAAHCE TADSGNGSDL ESTGLPTKPD DSEESGPSSL
GSDSMHGSST EYVRQSASQP SGQRQRQKSL RVLGALLPDS LLRDIRDRRS TEYVVQFSQP
EDEEKIQVPD KIPEKPSPFR LARESLSEDK IEELRAAVER ANFVQTGEET LDSIDATSQS
LPASSNIGGH RGNINYKYAD DQYYSFHINE HENFGARSAR SGDEADHSTG AGSEAGSDSG
ILTEQQDLFA GYRDVRCGAS STQSTIRSAK GTVRGVKNRV RNGIATFLQL QQQPNAKNFK
EKDLGKVVLY TTSMGIIRET YTKCANVKQI LRTLLVKFEE RDVFMSVEYQ AEMRQRMQSG
QVRVPQLYVE GQHIGDAETV ERMNESGELR QLLKPYKSMA STYTCQTCGG YRLLPCPSCN
GSKKSVHRNH FTAEFVALKC MNCDEVGLVK CHNC
