GRCR2_DROME
ID GRCR2_DROME Reviewed; 582 AA.
AC Q9W4S1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Glutaredoxin domain-containing cysteine-rich protein CG12206;
GN ORFNames=CG12206;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GRXCR1 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF45872.2; -; Genomic_DNA.
DR EMBL; AE014298; AAN09094.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09095.1; -; Genomic_DNA.
DR EMBL; BT009989; AAQ22458.1; -; mRNA.
DR RefSeq; NP_570060.1; NM_130704.2.
DR RefSeq; NP_726865.1; NM_166973.2.
DR RefSeq; NP_726866.1; NM_166974.1.
DR AlphaFoldDB; Q9W4S1; -.
DR SMR; Q9W4S1; -.
DR BioGRID; 57841; 2.
DR IntAct; Q9W4S1; 9.
DR STRING; 7227.FBpp0070503; -.
DR PaxDb; Q9W4S1; -.
DR DNASU; 31316; -.
DR EnsemblMetazoa; FBtr0070527; FBpp0070503; FBgn0029662.
DR EnsemblMetazoa; FBtr0070528; FBpp0070504; FBgn0029662.
DR EnsemblMetazoa; FBtr0070529; FBpp0070505; FBgn0029662.
DR GeneID; 31316; -.
DR KEGG; dme:Dmel_CG12206; -.
DR UCSC; CG12206-RA; d. melanogaster.
DR FlyBase; FBgn0029662; CG12206.
DR VEuPathDB; VectorBase:FBgn0029662; -.
DR eggNOG; KOG2824; Eukaryota.
DR GeneTree; ENSGT00940000171068; -.
DR HOGENOM; CLU_468745_0_0_1; -.
DR InParanoid; Q9W4S1; -.
DR OMA; PMRGISI; -.
DR OrthoDB; 686496at2759; -.
DR PhylomeDB; Q9W4S1; -.
DR BioGRID-ORCS; 31316; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31316; -.
DR PRO; PR:Q9W4S1; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0029662; Expressed in embryonic/larval tracheal system (Drosophila) and 19 other tissues.
DR Genevisible; Q9W4S1; DM.
DR GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..582
FT /note="Glutaredoxin domain-containing cysteine-rich protein
FT CG12206"
FT /id="PRO_0000349194"
FT DOMAIN 423..528
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT REGION 217..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 63369 MW; E485A5811FF61F86 CRC64;
MAAITSNVSR LEPMRGISII IESPEVATAT PPPATTTATA EAEAATKQVA PTAKSNSNTE
MSLKSQAAGM LLAFGDTAAT AKDNLETSYD TAAKSTAAPE TNKIYPQLLL RIGGEIAGAT
ASAEAAASAA TAAAATATSP TIISCNGEIA ASQAAATAAD TAATLQHNNT VKIQIESQGQ
QRTLGKQISV VKLNEGVEEM QQHMCYLVDT SGQYSPCETL DSGTGSDLEN HPQQQQQPQQ
VRSPQLELHL QTTRLMVNEE ADHKHSPLET PSPVPKRAYS LTDDSEECDE SSNSSLSCDS
LHSGGLLPTT LLRDIRFRER ASGPLVTKIN GRPLQFETDG YYTFHVREHE NFRSFGSNSS
TEYEAQHFTD EQPGEDFVGF RDIRTAGKLA GNSTIKSAKG TVRGVKNRVR NGVATFLQLQ
QPNVKNYMEK DVGKVVLYTT SMGIIRDTYA KCANVKKILR TLLIKFEERD IFMSVEYQQE
MRERMQDETI RVPQLFVEGQ LIGDANIVER LNESGELRQL LRPYKSIATA YTCQTCGGYR
MLPCPACNGS KKSMHRNHFT AEFVALKCMN CDEVGLIKCP NC
