GRCR2_MOUSE
ID GRCR2_MOUSE Reviewed; 254 AA.
AC Q3TYR5; Q3TYQ5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Glutaredoxin domain-containing cysteine-rich protein 2;
DE AltName: Full=GRXCR1-like protein;
DE AltName: Full=Glutaredoxin domain-containing cysteine-rich protein 1-like protein;
GN Name=Grxcr2; Synonyms=Gm851;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RA Avenarius M.R.;
RT "The glutaredoxin-like cysteine-rich family of genes, Grxcr1 and Grxcr2, in
RT stereocilia development and function.";
RL Thesis (2012), Univ. of Michigan, United States.
CC -!- FUNCTION: Could play a role in maintaining cochlear stereocilia bundles
CC that are involved in sound detection. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000269|Ref.3}.
CC -!- TISSUE SPECIFICITY: Expressed in sensory hair cells in the cochlea and
CC vestibular organ. {ECO:0000269|Ref.3}.
CC -!- DISRUPTION PHENOTYPE: Mice appear normal at postnatal week 2, but
CC develop progressive hearing loss associated with early defects in
CC orientation and organization of cochlear stereocilia bundles. They have
CC normal vestibular function. {ECO:0000269|Ref.3}.
CC -!- SIMILARITY: Belongs to the GRXCR1 family. {ECO:0000305}.
CC -!- CAUTION: Although it shares high sequence similarity with GRXCR1, it
CC does not contain a canonical glutaredoxin domain. {ECO:0000305}.
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DR EMBL; AK158418; BAE34497.1; -; mRNA.
DR EMBL; AK158432; BAE34507.1; -; mRNA.
DR EMBL; BC147102; AAI47103.1; -; mRNA.
DR EMBL; BC147103; AAI47104.1; -; mRNA.
DR CCDS; CCDS29209.1; -.
DR RefSeq; NP_001028598.1; NM_001033426.3.
DR AlphaFoldDB; Q3TYR5; -.
DR STRING; 10090.ENSMUSP00000095198; -.
DR PhosphoSitePlus; Q3TYR5; -.
DR PaxDb; Q3TYR5; -.
DR PRIDE; Q3TYR5; -.
DR ProteomicsDB; 271085; -.
DR Antibodypedia; 71010; 16 antibodies from 8 providers.
DR Ensembl; ENSMUST00000097591; ENSMUSP00000095198; ENSMUSG00000073574.
DR GeneID; 332309; -.
DR KEGG; mmu:332309; -.
DR UCSC; uc008etj.1; mouse.
DR CTD; 643226; -.
DR MGI; MGI:2685697; Grxcr2.
DR VEuPathDB; HostDB:ENSMUSG00000073574; -.
DR eggNOG; KOG2824; Eukaryota.
DR GeneTree; ENSGT00940000158849; -.
DR HOGENOM; CLU_067117_0_0_1; -.
DR InParanoid; Q3TYR5; -.
DR OMA; NDHKPPP; -.
DR OrthoDB; 1046721at2759; -.
DR PhylomeDB; Q3TYR5; -.
DR TreeFam; TF315372; -.
DR BioGRID-ORCS; 332309; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q3TYR5; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q3TYR5; protein.
DR Bgee; ENSMUSG00000073574; Expressed in morula.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005902; C:microvillus; IDA:MGI.
DR GO; GO:0120044; C:stereocilium base; IDA:MGI.
DR GO; GO:0120043; C:stereocilium shaft; IDA:MGI.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IMP:MGI.
DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IMP:MGI.
DR GO; GO:0033365; P:protein localization to organelle; IMP:MGI.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR InterPro; IPR033023; GRXCR2.
DR InterPro; IPR036410; HSP_DnaJ_Cys-rich_dom_sf.
DR PANTHER; PTHR46926; PTHR46926; 1.
DR SUPFAM; SSF57938; SSF57938; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Reference proteome.
FT CHAIN 1..254
FT /note="Glutaredoxin domain-containing cysteine-rich protein
FT 2"
FT /id="PRO_0000349192"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 28601 MW; CEEE120D57D093B0 CRC64;
MEDSEKKLNQ KSDDKPRKVR FKISSSYSGR VLKQVFEDGQ ELESPKEEYP HSFLQEALEP
MDGVYGSGEV PKPQPYSPKL TAQRISVFRD SGAYTLAGSQ PLFNDYKAND HKPPPIIDFG
KIIIYTNNLK IIRTPMDKRD FMRKILQKED VAEEASLMIT GENDGDREQG CPLPERNGSP
LPESERTFLH SQHTQDGLVP EDCLHCQGSG IATCSLCHGS KFSMLANRFK ESYRALRCPA
CNENGLQPCR ICSP
