ID   GRD2I_DANRE             Reviewed;        1009 AA.
AC   Q6ZM86;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Delphilin;
DE   AltName: Full=Glutamate receptor, ionotropic, delta 2-interacting protein 1;
GN   Name=grid2ip; ORFNames=si:ch211-147h1.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Postsynaptic scaffolding protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}.
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DR   EMBL; AL772266; CAE49895.1; -; Genomic_DNA.
DR   RefSeq; NP_001038368.1; NM_001044903.1.
DR   AlphaFoldDB; Q6ZM86; -.
DR   SMR; Q6ZM86; -.
DR   PaxDb; Q6ZM86; -.
DR   Ensembl; ENSDART00000161128; ENSDARP00000133025; ENSDARG00000095603.
DR   GeneID; 559717; -.
DR   KEGG; dre:559717; -.
DR   CTD; 559717; -.
DR   ZFIN; ZDB-GENE-040724-161; grid2ipb.
DR   eggNOG; KOG1922; Eukaryota.
DR   eggNOG; KOG3528; Eukaryota.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000157625; -.
DR   HOGENOM; CLU_002818_0_0_1; -.
DR   InParanoid; Q6ZM86; -.
DR   OMA; CENVPPS; -.
DR   OrthoDB; 790964at2759; -.
DR   PhylomeDB; Q6ZM86; -.
DR   TreeFam; TF329416; -.
DR   PRO; PR:Q6ZM86; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000095603; Expressed in brain and 14 other tissues.
DR   ExpressionAtlas; Q6ZM86; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF02181; FH2; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00498; FH2; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Postsynaptic cell membrane; Reference proteome;
KW   Synapse.
FT   CHAIN           1..1009
FT                   /note="Delphilin"
FT                   /id="PRO_0000331626"
FT   DOMAIN          95..172
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          629..1009
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          28..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          990..1009
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..440
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..496
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..604
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..629
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1009 AA;  113629 MW;  2836245DF69B12D4 CRC64;
     MFARIFIPKK HRQRFDEAVS QSLINRMCRS KSLGEPQNRL RRSRSQDHHE RPQGSKRASS
     VPRDTGDEPA QNDRTLRKSN TMIPTQYVSG VNQRTIRVYR GKKSFGFTLR GHAPVWIDSV
     MPGSPAEACG LKTGDRILFL NGLDMRNCSH EKVVSMLQGS GAMPSLVVEE GPVDYPQSDS
     EPEETPSAPR SRSPALSSLQ WVAEILPPSI RVHGRTFSQQ LEHLLTLQER YTICKALETF
     FQHRNVDTLI VDVFPVLDTP AKQLIWQFIY QLLTYEEQEH CKTKIARFLG FKSAGNRKSG
     LSLTWTDSFP GPQFETYQQT VASPDSVDSN PYVSLDSPPA SPLPSDELSP LPQRRKLFTF
     SRPPRSRDTD KFLDALSEQL GHRVNIVDDF KGGENDYEEM SFQDEQEVNM LPHELSSASS
     EDHSSSDDST SVSYSSGSDH IPPPPQSPPP PPPPLQFTDS PSPLPITPEH LPQPPPAFQH
     HPIIAPPPPP PRPFLANRPS LHKVLPTREE LRAQHSHPRR SSPQPSSQPI LQLHQPKAHP
     ILQSSPHTSP QPPHTSAQHT RLQHPSQSIY QSQQTTVPRT SPSLTKQKSL HSQPSQQSFE
     GTLSSKVPPP PPPPLPPPCD PPPLPKPSPK ASDNNHMSVK RLRWEQLGDD PDYHKLSDMV
     KYLDLDLYFG TQRNSKPTFL PENLKKKDVV EILSHKKAYN ASILIAHLKL APKELRDILM
     TMSTERLEPA HIKQLLLYAP DDEEVKQFQH YDQDPAKLSE PDQFVLQMLL VPEYKTRLRS
     LLFKTTVQEK TEEMRAAYEC IYKASLELKN SKRLAKILEF VLAMGNYLNN GQPKTNKTTG
     FKINFLTELN TTKTVDGKST FLHILAKSLC QHFPELLGFS RDLITVPLAA KVNQRTITAD
     LSDVHSTIQD IRTACVKIPA TAEDRFAAVM SSFLENCHPA VQSLDSLQQR AMDEFHKVAS
     YFGEDSKVTT TETFFGIFAE FISKFERALS ETQGTENPKS PRIASPLAW