ID   GRDH_ORYSJ              Reviewed;         300 AA.
AC   Q75KH3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Glucose and ribitol dehydrogenase homolog;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=Os05g0140800, LOC_Os05g04870;
GN   ORFNames=OJ1489_G03.3, OSJNBb0111O13.13;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: May act as a short alcohol-polyol-sugar dehydrogenase
CC       possibly related to carbohydrate metabolism and the acquisition of
CC       desiccation tolerance. May also be involved in signal transduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS90638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAU10779.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC105262; AAS90638.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC137621; AAU10779.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP014961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK110652; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q75KH3; -.
DR   SMR; Q75KH3; -.
DR   STRING; 4530.OS05T0140800-01; -.
DR   PaxDb; Q75KH3; -.
DR   PRIDE; Q75KH3; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   InParanoid; Q75KH3; -.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   Genevisible; Q75KH3; OS.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..300
FT                   /note="Glucose and ribitol dehydrogenase homolog"
FT                   /id="PRO_0000239260"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        205
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         44..68
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   300 AA;  32268 MW;  E1963CD5A5A3AFB4 CRC64;
     MASQQFPPQN QETQPGKEHA MDPRPEAIIQ SYKPANKLKD KVAIVTGGDS GIGRAVCLCF
     ALEGATVAFT YVKGQEEKDA EETLRALRDI RARTGAKDPM AIPADLGYDD NCRKVVDEVA
     GAYGGAIDIL VNNAAEQYER PSITDITEDD LERVFRTNIF SYFFMSKHAV KRMRDRRGGA
     GAGGCSIINT SSINAYKGNK TLLDYTATKG AIVAFTRALA LQLAEEGIRV NGVAPGPIWT
     PLIPASFAEE KVRQFGSQVP MGRAGQPSEV APSFVFLASD DASYMSGQML HVNGGVIVNG