ID   GREA_CHLMU              Reviewed;         714 AA.
AC   Q9PLU1;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Transcription elongation factor GreA;
DE   AltName: Full=Transcript cleavage factor GreA;
GN   Name=greA; OrderedLocusNames=TC_0004;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000305}.
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DR   EMBL; AE002160; AAF38898.1; -; Genomic_DNA.
DR   PIR; E81751; E81751.
DR   RefSeq; WP_010229079.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PLU1; -.
DR   SMR; Q9PLU1; -.
DR   STRING; 243161.TC_0004; -.
DR   EnsemblBacteria; AAF38898; AAF38898; TC_0004.
DR   GeneID; 1245527; -.
DR   KEGG; cmu:TC_0004; -.
DR   eggNOG; COG0782; Bacteria.
DR   eggNOG; COG1747; Bacteria.
DR   HOGENOM; CLU_026840_1_0_0; -.
DR   OMA; KKALHRY; -.
DR   OrthoDB; 1536415at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..714
FT                   /note="Transcription elongation factor GreA"
FT                   /id="PRO_0000177007"
FT   DOMAIN          1..502
FT                   /note="GRAD1"
FT   REGION          561..714
FT                   /note="GREA"
FT   COILED          602..639
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   714 AA;  80980 MW;  4220CA4E020157F6 CRC64;
     MDYLEKLQSL MENHPSDFFS LWEEYCFNDV VSGDELIVLL EKIKSSSIAP AFGKIAESVI
     PLWEQLPESE EKDKVLSLVF DIQTTNSKRL LELALQQVKK YEDSPNYKEA LRIVGLRDGI
     FFTHCLRHFA LLMHLCEGNF VFHQGGWGVG EIMGVSFLQQ KVLVEFEGVL TAKDISFETA
     FRMLSPLKKD HFLARRFGDP DAFEAFARKD PVAVIECLLK DLGPKNAKEI RNELVGLVIP
     EEDWSRWWQS AKIKMKKDSH ILAPTSSKDP YIFDPKGFSF ISQLQASLSG SNDASKKIAS
     CYTFVRDLGS ELKDEANRQF VIKELKSLDL PADSALSIQR AMLLSEFLGD KSSELDCENI
     AKLSEDQMFD IVNHIEILSF QKSFLSLIHS CSPAWVSVFT KILLTTSTSI LRDQVFKALI
     VDKKARESIL EKVSAMIEQP LLYPELFVWL FLRVVSGEDG LFSESDRKEI GRQMLASALE
     FMHKVAGSPQ KDLGKKLYSF LVGQRFLAIR QIIENASIDY LKEFVLLSSK CPQFTQGDLG
     VLRSLAEVVQ PALKRRVAEE ENILWTTSES FTRMKAKLQS LIGKEMVDNA KEIEDARALG
     DLRENSEYKF ALERRARLQE EIRVLSEEIN RAKILTKDAV FTNSVGVGCK VVLEDEQGEE
     DCYTILGPWD ANPEEKILSL KSKLAQEMVG KTVGESVLFQ GKKHKIKQIS SIWD