GREA_CHLPN
ID GREA_CHLPN Reviewed; 722 AA.
AC Q9Z7G4; Q9JQE9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Transcription elongation factor GreA;
DE AltName: Full=Transcript cleavage factor GreA;
GN Name=greA; OrderedLocusNames=CPn_0741, CP_0004, CpB0769;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000305}.
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DR EMBL; AE001363; AAD18880.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF37901.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98948.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98698.1; -; Genomic_DNA.
DR PIR; B86583; B86583.
DR PIR; C72040; C72040.
DR RefSeq; NP_224937.1; NC_000922.1.
DR RefSeq; WP_010883379.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7G4; -.
DR SMR; Q9Z7G4; -.
DR STRING; 115711.CP_0004; -.
DR EnsemblBacteria; AAD18880; AAD18880; CPn_0741.
DR EnsemblBacteria; AAF37901; AAF37901; CP_0004.
DR GeneID; 45051139; -.
DR KEGG; cpa:CP_0004; -.
DR KEGG; cpj:greA; -.
DR KEGG; cpn:CPn_0741; -.
DR KEGG; cpt:CpB0769; -.
DR PATRIC; fig|115713.3.peg.817; -.
DR eggNOG; COG0782; Bacteria.
DR eggNOG; COG1747; Bacteria.
DR HOGENOM; CLU_026840_1_0_0; -.
DR OrthoDB; 1536415at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.180; -; 1.
DR Gene3D; 3.10.50.30; -; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR PANTHER; PTHR30437; PTHR30437; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR SUPFAM; SSF46557; SSF46557; 1.
DR TIGRFAMs; TIGR01462; greA; 1.
DR PROSITE; PS00829; GREAB_1; 1.
DR PROSITE; PS00830; GREAB_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..722
FT /note="Transcription elongation factor GreA"
FT /id="PRO_0000177008"
FT DOMAIN 1..504
FT /note="GRAD1"
FT REGION 565..722
FT /note="GREA"
FT COILED 606..643
FT /evidence="ECO:0000255"
SQ SEQUENCE 722 AA; 82642 MW; E280EDB124D5E8CF CRC64;
MDYLEKLQVL IEEGQSANFL SLWEEYCFND VVRGRELVEI LEKVKSSSLA SLFGKIVDTV
VPLWEKIPEG KDKDRVLQLI LDLQTSNSQM FFDIATEYVN KKYSGEENFN EALRVVGLRD
GRDFQFSLSR FDFLMHMHKG NFVFHQGGWG VGEVMGVSFL QQKVLIEFEG IMSAKDISFE
TAFKSLTPLS GDHFLSRRFG DPDGFEAFAK ENPIEVVEIL LRDLGPKTAK EIKDELVDLV
IPEADWNRWW QSAKTKIKKG TRIISPDNPK EPYVLSDAGC SHMGQLERKL GLSLNSAEKI
SLIYHFIRDL HSELKNIEIR KSLVKALQDL DVEEGNKSLI LQRELLLSEY LGIKDASIDK
EYITSLSEDD TSRLLENMPI VALQKSFLSL VRKYSSFWQQ VFMQILLYTT SPTMRDFVYK
TIKNDPSSVE VLKKRLLDSA HQPMMFPELF VWFFLKLGNH EDGLFDPEDK EVLRLFLESA
LNFMYQVAST PHKELGKKLH HYLVGQRYLA VRQMIEGASL PFLKELLLLS TKCPQFSSSD
LNVLQSLAEV VQPTLKKHKS NVEEENVLWS TSESFSRMKA KLQSLVGKEM VDNAKEIEDA
RSLGDLRENS EYKFALEKRA RLQEEIRVLS EEINRARILT KDLVFTDKVG VGCKVTLKGD
AGEVVEYTIL GPWDADPDSC ILSLQSKLAQ NMLGKKLNDV VILQGKEYKI SRIQSIWEEH
GA
