ID   GREA_CHLTR              Reviewed;         715 AA.
AC   O84641;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Transcription elongation factor GreA;
DE   AltName: Full=Transcript cleavage factor GreA;
GN   Name=greA; OrderedLocusNames=CT_636;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC68240.1; -; Genomic_DNA.
DR   PIR; H71489; H71489.
DR   RefSeq; NP_220153.1; NC_000117.1.
DR   RefSeq; WP_009872006.1; NC_000117.1.
DR   AlphaFoldDB; O84641; -.
DR   SMR; O84641; -.
DR   STRING; 813.O172_03485; -.
DR   EnsemblBacteria; AAC68240; AAC68240; CT_636.
DR   GeneID; 884416; -.
DR   KEGG; ctr:CT_636; -.
DR   PATRIC; fig|272561.5.peg.696; -.
DR   HOGENOM; CLU_026840_1_0_0; -.
DR   InParanoid; O84641; -.
DR   OMA; KKALHRY; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IBA:GO_Central.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..715
FT                   /note="Transcription elongation factor GreA"
FT                   /id="PRO_0000177009"
FT   DOMAIN          1..502
FT                   /note="GRAD1"
FT   REGION          562..715
FT                   /note="GREA"
FT   COILED          603..640
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   715 AA;  80853 MW;  51F31448CBBAF970 CRC64;
     MDYLEKLQSL MENHPSDFFS LWEEYCFNDV VKGDELVVLL EKIKGSTIAP AFGKIAESVI
     PLWEQLPEGE EKDKVLSLVF DVQTTNSKNL LEIALQQVKK YEDSANYKEA LRIVGLRDGI
     TFSHCLGRFA LLMHLSEGNF VFHQGGWGVG EIMGVSFLQQ KVLVEFEGVL TAKDISFETA
     FRMLVPLRKD HFLARRFGDP DAFEAFARKE PVAAIECLLK DLGPKNAKEI RNELVELVIP
     EEDWSRWWQS AKIKMKKDAR ILAPASSKDP YVFDPKGFSF VSQLQASLSG SNDANKKITS
     CYAFVRDLGS ELKDESNRQL VIKELKALDL PADSALLIQR AMLLSEFLGE KAPELECENI
     AKLSEDQLFD IVNNIEILSL QKSFLALIHS CSPVWVPVYT KLFLTTSTSM LREQVFKVLN
     ADKEARENIL KKVFAMIEQP LLCPELFVWL FARVVDGEDG LFAESDKKEI ERQMLASALE
     LMHKVATTSQ KDLGKKLYSF LVGQRFLVVR QIIDQASIEY LKEFVLLSSK CPQFTQGDLG
     VLRSLAEVVQ PALKRGTPEE EENILWTTSD SFTRMKNKLQ SLVGKEMVEN AKEIEDARAL
     GDLRENSEYK IALERRARLQ EEIHVLSEEI NRAKILTKDA VFTDSVGVGC KVVLESDQGD
     KVCYTILGPW DANPDEKILS LKSKLAQEMV GKAVGETVLF QGKKHKIKEI SSIWD