GREA_MYCPU
ID GREA_MYCPU Reviewed; 157 AA.
AC Q98Q16;
DT 25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transcription elongation factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
DE AltName: Full=Transcript cleavage factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
GN Name=greA {ECO:0000255|HAMAP-Rule:MF_00105}; OrderedLocusNames=MYPU_5530;
OS Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX NCBI_TaxID=272635;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC {ECO:0000255|HAMAP-Rule:MF_00105}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000255|HAMAP-
CC Rule:MF_00105}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC13726.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL445565; CAC13726.1; ALT_INIT; Genomic_DNA.
DR PIR; A99581; A99581.
DR RefSeq; WP_041364168.1; NC_002771.1.
DR AlphaFoldDB; Q98Q16; -.
DR SMR; Q98Q16; -.
DR STRING; 272635.MYPU_5530; -.
DR PRIDE; Q98Q16; -.
DR EnsemblBacteria; CAC13726; CAC13726; CAC13726.
DR KEGG; mpu:MYPU_5530; -.
DR eggNOG; COG0782; Bacteria.
DR HOGENOM; CLU_101379_2_1_14; -.
DR OrthoDB; 1536415at2; -.
DR BioCyc; MPUL272635:G1GT6-566-MON; -.
DR Proteomes; UP000000528; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.180; -; 1.
DR Gene3D; 3.10.50.30; -; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR PANTHER; PTHR30437; PTHR30437; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF46557; SSF46557; 1.
DR TIGRFAMs; TIGR01462; greA; 1.
DR PROSITE; PS00830; GREAB_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..157
FT /note="Transcription elongation factor GreA"
FT /id="PRO_0000176942"
FT COILED 47..75
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00105"
SQ SEQUENCE 157 AA; 17814 MW; 56B1780263BCCFD7 CRC64;
MEEKNKIYLT QETIKKYEEE KWHLINVERP AVILEIKEAR QQGDLSENAE YDAAREKQGQ
IEDRITELEN ILSNAISIQE SHSDKIGLGS VVRILNQSTG KERTFKIVGS FDTDPTQNKI
SYESPLAKSI IGFSKGDVVE IDAPDKYTTK ILSVNDK
