GREA_RHILV
ID GREA_RHILV Reviewed; 158 AA.
AC O68546;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Transcription elongation factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
DE AltName: Full=Transcript cleavage factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
GN Name=greA {ECO:0000255|HAMAP-Rule:MF_00105};
OS Rhizobium leguminosarum bv. viciae.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=387;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=3855;
RX PubMed=9756877; DOI=10.1074/jbc.273.41.26432;
RA Kadrmas J.L., Allaway D., Studholme R.E., Sullivan J.T., Ronson C.W.,
RA Poole P.S., Raetz C.R.H.;
RT "Cloning and overexpression of glycosyltransferases that generate the
RT lipopolysaccharide core of Rhizobium leguminosarum.";
RL J. Biol. Chem. 273:26432-26440(1998).
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC {ECO:0000255|HAMAP-Rule:MF_00105}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000255|HAMAP-
CC Rule:MF_00105}.
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DR EMBL; AF050103; AAC05214.1; -; Genomic_DNA.
DR RefSeq; WP_003541639.1; NZ_WIEO01000031.1.
DR AlphaFoldDB; O68546; -.
DR SMR; O68546; -.
DR GeneID; 61424920; -.
DR OMA; TWLTQEA; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.180; -; 1.
DR Gene3D; 3.10.50.30; -; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR PANTHER; PTHR30437; PTHR30437; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF46557; SSF46557; 1.
DR TIGRFAMs; TIGR01462; greA; 1.
DR PROSITE; PS00829; GREAB_1; 1.
DR PROSITE; PS00830; GREAB_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..158
FT /note="Transcription elongation factor GreA"
FT /id="PRO_0000176960"
SQ SEQUENCE 158 AA; 17445 MW; FACA215D8CAF1605 CRC64;
MVEKVPMTPG GFVKLQEELR WRQQEERPRI IEAIAEARAH GDLSENAEYH AAKEAQSHNE
GRISELEDLT ARAEVIDLTK MSGDKIKFGA KVKLIDEDTE EEKTYQIVGD QEADVKAGRI
SISSPIARAL IGKEVGDSIE VNAPGGSKAY EILQVSWG