GREA_RHOBA
ID GREA_RHOBA Reviewed; 159 AA.
AC Q7UVA0;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Transcription elongation factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
DE AltName: Full=Transcript cleavage factor GreA {ECO:0000255|HAMAP-Rule:MF_00105};
GN Name=greA {ECO:0000255|HAMAP-Rule:MF_00105}; OrderedLocusNames=RB2780;
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC {ECO:0000255|HAMAP-Rule:MF_00105}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000255|HAMAP-
CC Rule:MF_00105}.
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DR EMBL; BX294137; CAD72826.1; -; Genomic_DNA.
DR RefSeq; NP_865142.1; NC_005027.1.
DR RefSeq; WP_007339475.1; NC_005027.1.
DR AlphaFoldDB; Q7UVA0; -.
DR SMR; Q7UVA0; -.
DR STRING; 243090.RB2780; -.
DR EnsemblBacteria; CAD72826; CAD72826; RB2780.
DR KEGG; rba:RB2780; -.
DR PATRIC; fig|243090.15.peg.1278; -.
DR eggNOG; COG0782; Bacteria.
DR HOGENOM; CLU_101379_2_0_0; -.
DR InParanoid; Q7UVA0; -.
DR OMA; TWLTQEA; -.
DR OrthoDB; 1536415at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0006354; P:DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.180; -; 1.
DR Gene3D; 3.10.50.30; -; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR018151; TF_GreA/GreB_CS.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR PANTHER; PTHR30437; PTHR30437; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF46557; SSF46557; 1.
DR TIGRFAMs; TIGR01462; greA; 1.
DR PROSITE; PS00829; GREAB_1; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..159
FT /note="Transcription elongation factor GreA"
FT /id="PRO_0000176962"
FT COILED 53..73
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00105"
SQ SEQUENCE 159 AA; 17671 MW; 6CA45985E24B35D2 CRC64;
MVESVPMTRE GYNKIKAEIN RMENEEMPMI VQKIAEAREE GDLKENAEYH AQRENQGMLM
AKINELRDKI ARASIIDVSS LPKDEVVFGC TVTVEDVAYG DEEQFTLVGA GDEDYDSGKI
LVTSPFGQGL VGKKVGETAE VDVPAGKLKF KILKIEFNL
