GREB1_MOUSE
ID GREB1_MOUSE Reviewed; 1954 AA.
AC Q3UHK3; E0CYB3; Q8BZT6; Q8CHE7; Q9JLG7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein GREB1;
GN Name=Greb1; Synonyms=Kiaa0575;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=10644441; DOI=10.1006/geno.1999.6023;
RA Peterfy M., Phan J., Oswell G.M., Xu P., Reue K.;
RT "Genetic, physical, and transcript map of the fld region on mouse
RT chromosome 12.";
RL Genomics 62:436-444(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1004-1954.
RC TISSUE=Embryonic tail;
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
CC -!- FUNCTION: May play a role in estrogen-stimulated cell proliferation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the GREB1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41432.2; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence={ECO:0000305};
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DR EMBL; AF180470; AAF44295.1; -; mRNA.
DR EMBL; AK033573; BAC28368.1; -; mRNA.
DR EMBL; AK147337; BAE27854.1; -; mRNA.
DR EMBL; AC122228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC157352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB093248; BAC41432.2; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS36408.1; -.
DR RefSeq; NP_056579.2; NM_015764.4.
DR RefSeq; XP_006515156.1; XM_006515093.2.
DR RefSeq; XP_006515157.1; XM_006515094.3.
DR RefSeq; XP_006515158.1; XM_006515095.3.
DR RefSeq; XP_006515159.1; XM_006515096.2.
DR RefSeq; XP_006515160.1; XM_006515097.3.
DR RefSeq; XP_006515161.1; XM_006515098.2.
DR AlphaFoldDB; Q3UHK3; -.
DR STRING; 10090.ENSMUSP00000124348; -.
DR iPTMnet; Q3UHK3; -.
DR PhosphoSitePlus; Q3UHK3; -.
DR PaxDb; Q3UHK3; -.
DR PRIDE; Q3UHK3; -.
DR ProteomicsDB; 271159; -.
DR Antibodypedia; 26843; 164 antibodies from 23 providers.
DR DNASU; 268527; -.
DR Ensembl; ENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523.
DR Ensembl; ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523.
DR GeneID; 268527; -.
DR KEGG; mmu:268527; -.
DR UCSC; uc029rrb.1; mouse.
DR CTD; 9687; -.
DR MGI; MGI:2149712; Greb1.
DR VEuPathDB; HostDB:ENSMUSG00000036523; -.
DR eggNOG; ENOG502QQXD; Eukaryota.
DR GeneTree; ENSGT00390000008041; -.
DR HOGENOM; CLU_237163_0_0_1; -.
DR InParanoid; Q3UHK3; -.
DR OMA; IFKGNCH; -.
DR OrthoDB; 70299at2759; -.
DR PhylomeDB; Q3UHK3; -.
DR TreeFam; TF329531; -.
DR Reactome; R-MMU-9018519; Estrogen-dependent gene expression.
DR BioGRID-ORCS; 268527; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Greb1; mouse.
DR PRO; PR:Q3UHK3; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3UHK3; protein.
DR Bgee; ENSMUSG00000036523; Expressed in embryonic post-anal tail and 140 other tissues.
DR ExpressionAtlas; Q3UHK3; baseline and differential.
DR Genevisible; Q3UHK3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028422; GREB1.
DR PANTHER; PTHR15720; PTHR15720; 1.
DR Pfam; PF15782; GREB1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1954
FT /note="Protein GREB1"
FT /id="PRO_0000320945"
FT TRANSMEM 1873..1893
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 48..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 230
FT /note="P -> T (in Ref. 1; AAF44295 and 2; BAE27854)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="A -> V (in Ref. 1; AAF44295)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="V -> A (in Ref. 1; AAF44295)"
FT /evidence="ECO:0000305"
FT CONFLICT 659
FT /note="E -> G (in Ref. 2; BAE27854)"
FT /evidence="ECO:0000305"
FT CONFLICT 844
FT /note="F -> Y (in Ref. 1; AAF44295)"
FT /evidence="ECO:0000305"
FT CONFLICT 1154
FT /note="A -> V (in Ref. 1; AAF44295, 2; BAE27854 and 4;
FT BAC41432)"
FT /evidence="ECO:0000305"
FT CONFLICT 1170
FT /note="S -> P (in Ref. 1; AAF44295, 2; BAE27854 and 4;
FT BAC41432)"
FT /evidence="ECO:0000305"
FT CONFLICT 1201
FT /note="G -> D (in Ref. 1; AAF44295 and 2; BAE27854)"
FT /evidence="ECO:0000305"
FT CONFLICT 1417
FT /note="Y -> C (in Ref. 1; AAF44295)"
FT /evidence="ECO:0000305"
FT CONFLICT 1749
FT /note="D -> N (in Ref. 2; BAC28368)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1954 AA; 216927 MW; 9EBBC2FF6F011E06 CRC64;
MGNSYAGQLK STRFEEVLHN SIEASLRSNT LVPRPIFSQL YLEAEQQLSS LEGGSRADNE
EEEEDGEGGL EPSSPPNAYQ LPPPPEGCCT TDGFCQAGKD LRLVSISSEP IEVPAGFLLV
GAKSPSLPDH LLVCAVDKRF LPDDNGHNAL LGFSGNCVGC GKKGFCYFTE FSNHINLKLT
TQPKKQKHLK YYLVRNAQGA LTKGPLICWK GSEFRGRQNS TNTCSSSLFP PLESSGSLAA
FPTEPVPGTN PSVPVGAQQA GPASDHPSVT TATGPAVFNG KDSPKHPQLV KSSLSALPRP
SALGILPNSG PPKKRHKGWS PESKSTTDGG FIQGGGNRAK HEGTSIPCVP QAGLVGPASV
TFPVVASGEP VSVPDNLLKI CKAKPVIFKG HGNFPYLCGN LNDVVVSPLL YTCYQNSQSL
ARAYEQHGAS TMQPISEETQ LLLTVYYLVQ LAADQVPLME DLEQIFLRSW RESHLTEIRQ
YQQAPPQPFP PATSTAAPVT SAQLPWLAGL AASSCNDSVH VIECAYSLAE GLSEMFRLLI
EGKLSKTNYV VIICACRNAA IDSCIAVTGK YQARILSESL LSPAEYQREV HYELVTGKVD
SLGTFFSSLC PEGDIDILLD KFHQENQGHV SSSFTASSTK KTAVLDASGV PVCTSYHQEP
RGVRPFQLAV AQKLLSHVCS IADSSTQNLD LGSFEKVDFL ICIPPSEVTY QQTVFHVWHS
GVLLELGLEK EPVTKQRAEQ HVLKLDTEAQ ARFKAFLQNS FQNPHTLFVL IHDHAHWDLV
SSAVHNIYSQ SDPSVGLVDR LLNCREVKEA PNIVTLHVTS FPYALQTQHT LISPYNEIHW
PISFSNGVDL YHESKKYFGL SEFIDSTLSG HSLPLLRYDS SFEAMVTALG KRFPRLHSAV
IRTFVLVQHY AAAMMAVSGL PQMKNHTSVE TLEITQNLLN SPKQCPCGHG LMVLLRVPCS
PLAAVAYERL AHVRARLALE EHFEIILGHP SSGITVGKHF VKQLKMWQKI EDAEWRPQTY
LELEGLPCIL IFSGMDPHGE SLPRSLRYCD LRLINSSCLV RTALEQELGL AAYFVSNDIP
LEKGPKNEAL ESDGEKLSST DEDEEAGTEG CFEAGSTSEQ RGPVKRERSH SHDSASSSLS
SRASGSVLYG ESLAQPSGPP QGELTRSPPS CGPAEEGRAP GEIQRLRVSQ GSTVISRHSP
GLVPQPDSSL RTGRRSLQVP AAPSSQLSSS SGSSSTCAVP TANVLVLQAS QCSMAKACRQ
PPIVFLPKLV YDMLLSTDSS GLPKSASLLP SPSVMWTSSF RPLLSKMMTS TEQSLYYRQW
TVPRPSHMDY GNRAEGRVDS FHPRRLLLSG PPQIGKTGAY LQFLSILSRM LIRLTEVDVY
DEEEINTSFR EESEWRYLQL ADPWPDLELF QKMPFDYIIH DPKYEDASLI CSHPQTIKSE
DRGMSRKPED LYVRRQTARM RLSKYAAYNT YHHCEQCQQY MGFHPHYQLS ESTLHVFAFS
CSMLGEEVQL HFIIPKSKEH HFVFSQPGGQ LESMRLPLVT DKSHEHIKSP TFTPTTGRHE
HGLFNLYHAM DGANHLHVLV VKEYEMAIYK KYWPNHIMLV LPSIFNSAGV GAAHFLIKEL
CYHNLELERN RQEELGVKPQ DVWPFIVIAD DSCVMWNVAD VDCAGERSRE FSWSERNVSL
KYIMLHIEAS PNITHYALLG MRKWASKTRG REVQEPFSRC HVHDFIILNV DLTQNVQYNQ
NRFTCDDVDF NLRVHSAGLL LCRFNRFSVM KKQIAVGGHR SFHITSKVSD SSVAIVPSQY
ICAPDSKHTF LAAPAQLLLE KFLQYHSHRF FPLSLKNHSH PVLSVDCYLN LGPQISVCYV
SSRPHSLNIS CSDMVFSGLL LYLCDSFVGA SFLKKFHFLK GATLCVICQD RNSLRQTVVR
LELEDEWQFR LRDEFQTANA KEDRPLFFLT ARHI
