ID   GREB_NEIMB              Reviewed;         163 AA.
AC   Q9K0C5;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Transcription elongation factor GreB {ECO:0000255|HAMAP-Rule:MF_00930};
DE   AltName: Full=Transcript cleavage factor GreB {ECO:0000255|HAMAP-Rule:MF_00930};
GN   Name=greB {ECO:0000255|HAMAP-Rule:MF_00930}; OrderedLocusNames=NMB0689;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreB releases sequences of up to 9 nucleotides in length.
CC       {ECO:0000255|HAMAP-Rule:MF_00930}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. GreB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00930}.
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DR   EMBL; AE002098; AAF41107.1; -; Genomic_DNA.
DR   PIR; H81169; H81169.
DR   RefSeq; NP_273731.1; NC_003112.2.
DR   RefSeq; WP_002225493.1; NC_003112.2.
DR   AlphaFoldDB; Q9K0C5; -.
DR   SMR; Q9K0C5; -.
DR   STRING; 122586.NMB0689; -.
DR   PaxDb; Q9K0C5; -.
DR   EnsemblBacteria; AAF41107; AAF41107; NMB0689.
DR   KEGG; nme:NMB0689; -.
DR   PATRIC; fig|122586.8.peg.874; -.
DR   HOGENOM; CLU_101379_3_0_4; -.
DR   OMA; DQIFFGA; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IBA:GO_Central.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   HAMAP; MF_00930; GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   InterPro; IPR006358; Tscrpt_elong_fac_GreB.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01461; greB; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..163
FT                   /note="Transcription elongation factor GreB"
FT                   /id="PRO_0000176948"
FT   COILED          54..76
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00930"
SQ   SEQUENCE   163 AA;  18666 MW;  E10073949DCC2F65 CRC64;
     MSTETKNYIT PAGWQALKDE LYQLVNKERP EIVQIVNWAA GNGDRSENGD YLYGKRRMRE
     IDRRIRFLTK RLEAAVVVDP ELREATDQVF FGATVGLLRD DGREQTVKIV GIDEIDTAQN
     KISWISPLAR CLIKAREGDE VVLNTPEGRE EIEILSVEYI KID