GREM1_CHICK
ID GREM1_CHICK Reviewed; 184 AA.
AC O73755;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Gremlin-1;
DE Flags: Precursor;
GN Name=GREM1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9660951; DOI=10.1016/s1097-2765(00)80067-2;
RA Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.;
RT "The Xenopus dorsalizing factor Gremlin identifies a novel family of
RT secreted proteins that antagonize BMP activities.";
RL Mol. Cell 1:673-683(1998).
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=14991724; DOI=10.1002/dvdy.10432;
RA Huillard E., Marx M.;
RT "Localized expression of drm/gremlin in the central nervous system of the
RT chicken embryo.";
RL Dev. Dyn. 229:688-694(2004).
CC -!- FUNCTION: Cytokine that may play a role in the development of the
CC medial pallium and during optic nerve and pecten development by
CC modulating BMP signaling. {ECO:0000269|PubMed:14991724}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: In brain first detected at E6 and persisted until
CC E14. On E10 brain, expressed in the dorsal region of the telencephalic
CC hemispheres and cells located in the ventral diencephalon. On E14 head,
CC expressed in the meninges of the spinal cord. Expressed in the
CC developing optic nerve and at the optic nerve/pecten junction.
CC {ECO:0000269|PubMed:14991724}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR EMBL; AF045799; AAC41280.1; -; mRNA.
DR RefSeq; NP_990309.1; NM_204978.2.
DR AlphaFoldDB; O73755; -.
DR SMR; O73755; -.
DR STRING; 9031.ENSGALP00000037126; -.
DR PaxDb; O73755; -.
DR Ensembl; ENSGALT00000015827; ENSGALP00000037126; ENSGALG00000009724.
DR GeneID; 395826; -.
DR KEGG; gga:395826; -.
DR CTD; 26585; -.
DR VEuPathDB; HostDB:geneid_395826; -.
DR eggNOG; ENOG502QQ5X; Eukaryota.
DR GeneTree; ENSGT00940000154209; -.
DR HOGENOM; CLU_101024_0_0_1; -.
DR InParanoid; O73755; -.
DR OMA; MPRTRCA; -.
DR OrthoDB; 1270652at2759; -.
DR PhylomeDB; O73755; -.
DR TreeFam; TF106445; -.
DR PRO; PR:O73755; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000009724; Expressed in colon and 6 other tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0043184; F:vascular endothelial growth factor receptor 2 binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; IEA:Ensembl.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; ISS:AgBase.
DR GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR GO; GO:1900158; P:negative regulation of bone mineralization involved in bone maturation; IEA:Ensembl.
DR GO; GO:0046851; P:negative regulation of bone remodeling; IEA:Ensembl.
DR GO; GO:1900155; P:negative regulation of bone trabecula formation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; ISS:AgBase.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
DR GO; GO:0090291; P:negative regulation of osteoclast proliferation; IEA:Ensembl.
DR GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; IEA:Ensembl.
DR GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl.
DR GO; GO:0051973; P:positive regulation of telomerase activity; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0051893; P:regulation of focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IBA:GO_Central.
DR GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR017159; Gremlin-1/2.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR SMART; SM00041; CT; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..184
FT /note="Gremlin-1"
FT /id="PRO_0000006718"
FT DOMAIN 94..184
FT /note="CTCK"
FT REGION 24..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..144
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 108..158
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 118..176
FT /evidence="ECO:0000250|UniProtKB:O60565"
FT DISULFID 122..178
FT /evidence="ECO:0000250|UniProtKB:O60565"
SQ SEQUENCE 184 AA; 21166 MW; 3510B44E8F6DD5EA CRC64;
MVRTLYAIGA VFLLTGFLLP TAEGRKRNRG SQGAIPPPDK DQPNDSEQMQ TQQQSGSRHR
ERGKGTSMPA EEVLESSQEA LHITERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG
QCNSFYIPRH VRKEEGSFQS CSFCKPKKFT TMTVTLNCPE LQPPRKKKRI TRVKECRCIS
IDLD
