GRF1_MAIZE
ID GRF1_MAIZE Reviewed; 408 AA.
AC A0A060D764; A5HEG0;
DT 07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Growth-regulating factor 1 {ECO:0000303|Ref.1};
DE Short=ZmGRF1 {ECO:0000303|Ref.1};
DE AltName: Full=Growth-regulating factor 6 {ECO:0000312|EMBL:AIB05463.1};
GN Name=GRF1 {ECO:0000303|Ref.1}; Synonyms=GRF6 {ECO:0000312|EMBL:AIB05463.1};
GN ORFNames=ZEAMMB73_Zm00001d017742 {ECO:0000312|EMBL:AQK73911.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX AGRICOLA=IND44119307; DOI=10.1016/j.plantsci.2008.08.002;
RA Zhang D.F., Li B., Jia G.Q., Zhang T.F., Dai J.R., Li J.S., Wang S.C.;
RT "Isolation and characterization of genes encoding GRF transcription factors
RT and GIF transcriptional coactivators in Maize (Zea mays L.).";
RL Plant Sci. 175:809-817(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Burdo B., Gray J., Goetting-Minesky M.P., Wittler B., Hunt M., Li T.,
RA Velliquette D., Thomas J., Gentzel I., Dos Santos Brito M.,
RA Mejia-Guerra M.K., Connolly L.N., Qaisi D., Li W., Casas M.I., Doseff A.I.,
RA Grotewold E.;
RT "The Maize TFome - Development of a transcription factor open reading frame
RT collection for functional genomics.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yadava P., Verma R., Singh I.;
RT "Role of growth regulating factor (Angustifolia-AN3) in drought tolerance
RT in maize.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [5]
RP INTERACTION WITH GIF1, AND TISSUE SPECIFICITY.
RX PubMed=24854713; DOI=10.1111/jipb.12220;
RA Wu L., Zhang D., Xue M., Qian J., He Y., Wang S.;
RT "Overexpression of the maize GRF10, an endogenous truncated growth-
RT regulating factor protein, leads to reduction in leaf size and plant
RT height.";
RL J. Integr. Plant Biol. 56:1053-1063(2014).
RN [6]
RP FUNCTION.
RX PubMed=26036253; DOI=10.1105/tpc.15.00269;
RA Nelissen H., Eeckhout D., Demuynck K., Persiau G., Walton A., van Bel M.,
RA Vervoort M., Candaele J., De Block J., Aesaert S., Van Lijsebettens M.,
RA Goormachtig S., Vandepoele K., Van Leene J., Muszynski M., Gevaert K.,
RA Inze D., De Jaeger G.;
RT "Dynamic changes in ANGUSTIFOLIA3 complex composition reveal a growth
RT regulatory mechanism in the maize leaf.";
RL Plant Cell 27:1605-1619(2015).
CC -!- FUNCTION: Transcription activator that plays a role in the regulation
CC of cell expansion in developing leaves (PubMed:26036253). Component of
CC a network formed by the microRNA396 (miRNA396), the GRFs and their
CC interacting factors (GIFs) acting in the regulation of meristem
CC function and the transition between cell division and cell expansion in
CC growing leaves (PubMed:26036253). {ECO:0000269|PubMed:26036253}.
CC -!- SUBUNIT: Interacts with GIF1. {ECO:0000269|PubMed:24854713}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
CC -!- TISSUE SPECIFICITY: Highly expressed in developing leaves.
CC {ECO:0000269|PubMed:24854713, ECO:0000269|Ref.1}.
CC -!- DOMAIN: The QLQ domain and WRC domain may be involved in protein-
CC protein interaction and DNA-binding, respectively. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GRF family. {ECO:0000305}.
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DR EMBL; EF515840; ABQ01214.1; -; mRNA.
DR EMBL; KJ727972; AIB05463.1; -; mRNA.
DR EMBL; KX494923; AOY34552.1; -; mRNA.
DR EMBL; CM000781; AQK73911.1; -; Genomic_DNA.
DR RefSeq; NP_001106021.1; NM_001112551.1.
DR AlphaFoldDB; A0A060D764; -.
DR STRING; 4577.GRMZM2G034876_P01; -.
DR EnsemblPlants; Zm00001eb251820_T003; Zm00001eb251820_P003; Zm00001eb251820.
DR GeneID; 100101535; -.
DR Gramene; Zm00001eb251820_T003; Zm00001eb251820_P003; Zm00001eb251820.
DR KEGG; zma:100101535; -.
DR eggNOG; ENOG502QSFK; Eukaryota.
DR OMA; FCRSTPL; -.
DR OrthoDB; 1097140at2759; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; A0A060D764; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0048366; P:leaf development; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR InterPro; IPR031137; GRF.
DR InterPro; IPR014977; WRC_dom.
DR PANTHER; PTHR31602; PTHR31602; 1.
DR Pfam; PF08880; QLQ; 1.
DR Pfam; PF08879; WRC; 1.
DR SMART; SM00951; QLQ; 1.
DR PROSITE; PS51666; QLQ; 1.
DR PROSITE; PS51667; WRC; 1.
PE 1: Evidence at protein level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..408
FT /note="Growth-regulating factor 1"
FT /id="PRO_0000445647"
FT DOMAIN 59..94
FT /note="QLQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01001"
FT DOMAIN 120..164
FT /note="WRC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT REGION 139..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 125..135
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT MOTIF 153..160
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT CONFLICT 191
FT /note="T -> A (in Ref. 1; ABQ01214 and 3; AOY34552)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="A -> V (in Ref. 1; ABQ01214 and 3; AOY34552)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="W -> R (in Ref. 1; ABQ01214 and 3; AOY34552)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="F -> S (in Ref. 1; ABQ01214 and 3; AOY34552)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 42655 MW; A589838630574164 CRC64;
MAMPYASLSP AGAADHRSST ATASLVPFCR STPLSAGGGL GEEDAQASAR WPAARPVVPF
TPAQYQELEQ QALIYKYLVA GVPVPPDLVV PIRRGLDSLA TRFYGQPTLG YGPYLGRKLD
PEPGRCRRTD GKKWRCSKEA APDSKYCERH MHRGRNRSRK PVETQLAPQS QPPAAAAVSA
APPLAAAAAA TTNGSGFQNH SLYPAIAGST GGGGGVGGSG NISSPFSSSM GGSSQLHMDS
AASYSYAALG GGTAKDLRYN AYGIRSLADE HNQLIAEAID SSIESQWRLP SSSFPLSSYP
HLGALGDLGG QNSTVSSLPK MEKQQPPSSF LGNDTGAGMA MGSASAKQEG QTLRHFFDEW
PKARDSWPGL SDETASLASF PPATQLSMSI PMASSDFSVA SSQSPNDD
