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GRF5_ARATH
ID   GRF5_ARATH              Reviewed;         397 AA.
AC   Q8L8A6; C0SVA9; Q9LVK4;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Growth-regulating factor 5;
DE            Short=AtGRF5;
DE   AltName: Full=Transcription activator GRF5;
GN   Name=GRF5; OrderedLocusNames=At3g13960; ORFNames=MDC16.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, NOMENCLATURE, AND
RP   TISSUE SPECIFICITY.
RX   PubMed=12974814; DOI=10.1046/j.1365-313x.2003.01862.x;
RA   Kim J.H., Choi D., Kende H.;
RT   "The AtGRF family of putative transcription factors is involved in leaf and
RT   cotyledon growth in Arabidopsis.";
RL   Plant J. 36:94-104(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-397 (ISOFORM 2).
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA   Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION.
RX   PubMed=15326298; DOI=10.1073/pnas.0405450101;
RA   Kim J.H., Kende H.;
RT   "A transcriptional coactivator, AtGIF1, is involved in regulating leaf
RT   growth and morphology in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13374-13379(2004).
RN   [6]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INTERACTION WITH
RP   GIF1.
RX   PubMed=15960617; DOI=10.1111/j.1365-313x.2005.02429.x;
RA   Horiguchi G., Kim G.T., Tsukaya H.;
RT   "The transcription factor AtGRF5 and the transcription coactivator AN3
RT   regulate cell proliferation in leaf primordia of Arabidopsis thaliana.";
RL   Plant J. 43:68-78(2005).
RN   [7]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=20023165; DOI=10.1242/dev.043067;
RA   Rodriguez R.E., Mecchia M.A., Debernardi J.M., Schommer C., Weigel D.,
RA   Palatnik J.F.;
RT   "Control of cell proliferation in Arabidopsis thaliana by microRNA
RT   miR396.";
RL   Development 137:103-112(2010).
CC   -!- FUNCTION: Transcription activator that plays a role in the regulation
CC       of cell expansion in leaf and cotyledons tissues. Acts together with
CC       GIF1 for the development of appropriate leaf size and shape through the
CC       promotion and/or maintenance of cell proliferation activity in leaf
CC       primordia. {ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:15960617}.
CC   -!- SUBUNIT: Interacts with GIF1. {ECO:0000269|PubMed:15960617}.
CC   -!- INTERACTION:
CC       Q8L8A6; Q39011: ASK7; NbExp=3; IntAct=EBI-1396652, EBI-1798250;
CC       Q8L8A6; Q94ID6: ERF12; NbExp=3; IntAct=EBI-1396652, EBI-4446727;
CC       Q8L8A6; Q8L8A5: GIF1; NbExp=4; IntAct=EBI-1396652, EBI-1396623;
CC       Q8L8A6; Q9MAL9: GIF2; NbExp=3; IntAct=EBI-1396652, EBI-1396863;
CC       Q8L8A6; Q93VH6: GIF3; NbExp=3; IntAct=EBI-1396652, EBI-15194507;
CC       Q8L8A6; Q9C5X0: IAA34; NbExp=3; IntAct=EBI-1396652, EBI-3946459;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8L8A6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8L8A6-2; Sequence=VSP_044146;
CC   -!- TISSUE SPECIFICITY: Strongly expressed in actively growing and
CC       developing tissues, such as roots, upper stems, and shoot tips
CC       containing the shoot apical meristem (SAM) and flower buds. Also
CC       expressed in mature flowers, but weakly expressed in mature stems and
CC       leaves. {ECO:0000269|PubMed:12974814, ECO:0000269|PubMed:15960617}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during the early stages of leaf
CC       development and expression decreases with the maturation of the leaf.
CC       {ECO:0000269|PubMed:20023165}.
CC   -!- DOMAIN: The QLQ domain and WRC domain may be involved in protein-
CC       protein interaction and DNA-binding, respectively.
CC   -!- DISRUPTION PHENOTYPE: Small and narrow leaves.
CC       {ECO:0000269|PubMed:15960617}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRF family. {ECO:0000305}.
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DR   EMBL; AY102638; AAM52880.1; -; mRNA.
DR   EMBL; AB019229; BAB02326.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75445.1; -; Genomic_DNA.
DR   EMBL; AB493612; BAH30450.1; -; mRNA.
DR   RefSeq; NP_188012.2; NM_112250.3. [Q8L8A6-1]
DR   AlphaFoldDB; Q8L8A6; -.
DR   BioGRID; 5943; 33.
DR   IntAct; Q8L8A6; 33.
DR   STRING; 3702.AT3G13960.1; -.
DR   PaxDb; Q8L8A6; -.
DR   PRIDE; Q8L8A6; -.
DR   ProteomicsDB; 247287; -. [Q8L8A6-1]
DR   EnsemblPlants; AT3G13960.1; AT3G13960.1; AT3G13960. [Q8L8A6-1]
DR   GeneID; 820609; -.
DR   Gramene; AT3G13960.1; AT3G13960.1; AT3G13960. [Q8L8A6-1]
DR   KEGG; ath:AT3G13960; -.
DR   Araport; AT3G13960; -.
DR   TAIR; locus:2088272; AT3G13960.
DR   eggNOG; ENOG502RAHZ; Eukaryota.
DR   HOGENOM; CLU_037908_1_0_1; -.
DR   InParanoid; Q8L8A6; -.
DR   OMA; MDAYSNS; -.
DR   PhylomeDB; Q8L8A6; -.
DR   PRO; PR:Q8L8A6; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8L8A6; baseline and differential.
DR   Genevisible; Q8L8A6; AT.
DR   GO; GO:0005634; C:nucleus; ISS:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0048366; P:leaf development; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0009409; P:response to cold; IEP:TAIR.
DR   GO; GO:0009739; P:response to gibberellin; IMP:TAIR.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR   InterPro; IPR031137; GRF.
DR   InterPro; IPR014977; WRC_dom.
DR   PANTHER; PTHR31602; PTHR31602; 1.
DR   Pfam; PF08880; QLQ; 1.
DR   Pfam; PF08879; WRC; 1.
DR   SMART; SM00951; QLQ; 1.
DR   PROSITE; PS51666; QLQ; 1.
DR   PROSITE; PS51667; WRC; 1.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..397
FT                   /note="Growth-regulating factor 5"
FT                   /id="PRO_0000419296"
FT   DOMAIN          16..51
FT                   /note="QLQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01001"
FT   DOMAIN          81..125
FT                   /note="WRC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT   REGION          108..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          288..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           78..96
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT   MOTIF           114..121
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT   COMPBIAS        122..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..371
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         397
FT                   /note="S -> N (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.4"
FT                   /id="VSP_044146"
SQ   SEQUENCE   397 AA;  44696 MW;  706BE379D661DD43 CRC64;
     MMSLSGSSGR TIGRPPFTPT QWEELEHQAL IYKYMVSGVP VPPELIFSIR RSLDTSLVSR
     LLPHQSLGWG CYQMGFGRKP DPEPGRCRRT DGKKWRCSRE AYPDSKYCEK HMHRGRNRAR
     KSLDQNQTTT TPLTSPSLSF TNNNNPSPTL SSSSSSNSSS TTYSASSSSM DAYSNSNRFG
     LGGSSSNTRG YFNSHSLDYP YPSTSPKQQQ QTLHHASALS LHQNTNSTSQ FNVLASATDH
     KDFRYFQGIG ERVGGVGERT FFPEASRSFQ DSPYHHHQQP LATVMNDPYH HCSTDHNKID
     HHHTYSSSSS SQHLHHDHDH RQQQCFVLGA DMFNKPTRSV LANSSRQDQN QEEDEKDSSE
     SSKKSLHHFF GEDWAQNKNS SDSWLDLSSH SRLDTGS
 
 
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