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GRF6_ARATH
ID   GRF6_ARATH              Reviewed;         244 AA.
AC   Q9ZQ12; Q8W4R5;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Growth-regulating factor 6;
DE            Short=AtGRF6;
DE   AltName: Full=Transcription activator GRF6;
GN   Name=GRF6; OrderedLocusNames=At2g06200; ORFNames=F5K7.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=12974814; DOI=10.1046/j.1365-313x.2003.01862.x;
RA   Kim J.H., Choi D., Kende H.;
RT   "The AtGRF family of putative transcription factors is involved in leaf and
RT   cotyledon growth in Arabidopsis.";
RL   Plant J. 36:94-104(2003).
RN   [5]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=20023165; DOI=10.1242/dev.043067;
RA   Rodriguez R.E., Mecchia M.A., Debernardi J.M., Schommer C., Weigel D.,
RA   Palatnik J.F.;
RT   "Control of cell proliferation in Arabidopsis thaliana by microRNA
RT   miR396.";
RL   Development 137:103-112(2010).
CC   -!- FUNCTION: Transcription activator that plays a role in the regulation
CC       of cell expansion in leaf and cotyledons tissues. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9ZQ12; Q8L8A5: GIF1; NbExp=3; IntAct=EBI-15193797, EBI-1396623;
CC       Q9ZQ12; Q9MAL9: GIF2; NbExp=3; IntAct=EBI-15193797, EBI-1396863;
CC       Q9ZQ12; Q93VH6: GIF3; NbExp=3; IntAct=EBI-15193797, EBI-15194507;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in actively growing and
CC       developing tissues, such as roots, upper stems, and shoot tips
CC       containing the shoot apical meristem (SAM) and flower buds. Also
CC       expressed in mature flowers, but weakly expressed in mature stems and
CC       leaves. {ECO:0000269|PubMed:12974814}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during the early stages of leaf
CC       development and expression decreases with the maturation of the leaf.
CC       {ECO:0000269|PubMed:20023165}.
CC   -!- DOMAIN: The QLQ domain and WRC domain may be involved in protein-
CC       protein interaction and DNA-binding, respectively.
CC   -!- SIMILARITY: Belongs to the GRF family. {ECO:0000305}.
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DR   EMBL; AC006413; AAD19769.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06004.1; -; Genomic_DNA.
DR   EMBL; AY060586; AAL31211.1; -; mRNA.
DR   EMBL; AY125572; AAM78082.1; -; mRNA.
DR   PIR; A84476; A84476.
DR   RefSeq; NP_027759.1; NM_126630.2.
DR   AlphaFoldDB; Q9ZQ12; -.
DR   BioGRID; 575; 7.
DR   IntAct; Q9ZQ12; 7.
DR   STRING; 3702.AT2G06200.1; -.
DR   iPTMnet; Q9ZQ12; -.
DR   PaxDb; Q9ZQ12; -.
DR   ProteomicsDB; 247037; -.
DR   EnsemblPlants; AT2G06200.1; AT2G06200.1; AT2G06200.
DR   GeneID; 815176; -.
DR   Gramene; AT2G06200.1; AT2G06200.1; AT2G06200.
DR   KEGG; ath:AT2G06200; -.
DR   Araport; AT2G06200; -.
DR   TAIR; locus:2051597; AT2G06200.
DR   eggNOG; ENOG502RAHZ; Eukaryota.
DR   HOGENOM; CLU_1130408_0_0_1; -.
DR   OMA; YEMGKER; -.
DR   PhylomeDB; Q9ZQ12; -.
DR   PRO; PR:Q9ZQ12; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZQ12; baseline and differential.
DR   Genevisible; Q9ZQ12; AT.
DR   GO; GO:0005634; C:nucleus; ISS:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0048366; P:leaf development; TAS:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR   InterPro; IPR031137; GRF.
DR   InterPro; IPR014977; WRC_dom.
DR   PANTHER; PTHR31602; PTHR31602; 1.
DR   Pfam; PF08880; QLQ; 1.
DR   Pfam; PF08879; WRC; 1.
DR   SMART; SM00951; QLQ; 1.
DR   PROSITE; PS51666; QLQ; 1.
DR   PROSITE; PS51667; WRC; 1.
PE   1: Evidence at protein level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Growth-regulating factor 6"
FT                   /id="PRO_0000419297"
FT   DOMAIN          6..41
FT                   /note="QLQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01001"
FT   DOMAIN          80..124
FT                   /note="WRC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT   REGION          107..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           77..95
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
FT   MOTIF           113..122
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01002"
SQ   SEQUENCE   244 AA;  28211 MW;  BC596F0CE9220C61 CRC64;
     MATRIPFTES QWEELENQAL VFKYLAANMP VPPHLLFLIK RPFLFSSSSS SSSSSSFFSP
     TLSPHFGWNV YEMGMGRKID AEPGRCRRTD GKKWRCSKEA YPDSKYCERH MHRGKNRSSS
     RKPPPTQFTP NLFLDSSSRR RRSGYMDDFF SIEPSGSIKS CSGSAMEDND DGSCRGINNE
     EKQPDRHCFI LGTDLRTRER PLMLEEKLKQ RDHDNEEEQG SKRFYRFLDE WPSSKSSVST
     SLFI
 
 
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