ID   GRFA_CAMPM              Reviewed;         139 AA.
AC   Q8V307;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=Growth factor;
DE   AltName: Full=Secreted epidermal growth factor-like;
DE   Flags: Precursor;
GN   OrderedLocusNames=CMLV010;
OS   Camelpox virus (strain M-96).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203173;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12033760; DOI=10.1006/viro.2001.1343;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Sandybaev N.T., Kerembekova U.Z.,
RA   Zaitsev V.L., Kutish G.F., Rock D.L.;
RT   "The genome of camelpox virus.";
RL   Virology 295:1-9(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AF438165; AAL73717.1; -; Genomic_DNA.
DR   RefSeq; NP_570400.1; NC_003391.1.
DR   GeneID; 932511; -.
DR   KEGG; vg:932511; -.
DR   Proteomes; UP000152221; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; IEA:InterPro.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR015497; EGF_rcpt_ligand.
DR   InterPro; IPR011170; GF_C11R.
DR   PANTHER; PTHR10740; PTHR10740; 1.
DR   PIRSF; PIRSF001779; GF_C11R; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Growth factor; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..139
FT                   /note="Growth factor"
FT                   /id="PRO_0000007601"
FT   DOMAIN          41..81
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        45..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        53..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        71..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   139 AA;  15483 MW;  587C8F68A821E0F3 CRC64;
     MSMKYLMLLF ATMIIRSFAD SGNAIETTSP EITNTTTDIP AIRLCGPEGD GYCLHGDCIH
     ARDINGMYCR CSHGYTGIRC QHVVLVDYQR SEKPNTTTSY IPSPGIVLVL VGIIMCCLLS
     VYRFTRRTNK LPLQDMVVP