GRFA_RFVKA
ID GRFA_RFVKA Reviewed; 80 AA.
AC P08441; Q77PC4;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 29-SEP-2021, entry version 94.
DE RecName: Full=Growth factor;
DE AltName: Full=Secreted epidermal growth factor-like;
DE Flags: Precursor;
GN ORFNames=s010L;
OS Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS Kasza)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX NCBI_TaxID=10272;
OH NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3031480; DOI=10.1128/mcb.7.1.535-540.1987;
RA Chang W., Upton C., Hu S.-L., Purchio A.F., McFadden G.;
RT "The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a
RT growth factor gene with sequence similarity to those encoding epidermal
RT growth factor and transforming growth factor alpha.";
RL Mol. Cell. Biol. 7:535-540(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2173269; DOI=10.1016/0042-6822(90)90170-v;
RA Chang W., Macaulay C., Hu S.L., Tam J.P., McFadden G.;
RT "Tumorigenic poxviruses: characterization of the expression of an epidermal
RT growth factor related gene in Shope fibroma virus.";
RL Virology 179:926-930(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1660196; DOI=10.1016/0042-6822(91)90529-k;
RA Strayer D.S., Jerng H.H., O'Connor K.;
RT "Sequence and analysis of a portion of the genomes of Shope fibroma virus
RT and malignant rabbit fibroma virus that is important for viral replication
RT in lymphocytes.";
RL Virology 185:585-595(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA Willer D.O., McFadden G., Evans D.H.;
RT "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL Virology 264:319-343(1999).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; M15921; AAA66873.1; -; Genomic_DNA.
DR EMBL; AF170722; AAF17894.1; -; Genomic_DNA.
DR PIR; A26723; EGVZSF.
DR RefSeq; NP_051899.1; NC_001266.1.
DR SMR; P08441; -.
DR GeneID; 1486856; -.
DR KEGG; vg:1486856; -.
DR Proteomes; UP000000868; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000742; EGF-like_dom.
DR Pfam; PF00008; EGF; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 3: Inferred from homology;
KW Disulfide bond; EGF-like domain; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..80
FT /note="Growth factor"
FT /id="PRO_0000007605"
FT DOMAIN 29..73
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 33..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 41..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 63..72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 80 AA; 9210 MW; C48D30E878D2ED58 CRC64;
MATRNLVASL LCIMYAVHAM NDYLYIVKHV KVCNHDYENY CLNNGTCFTI ALDNVSITPF
CVCRINYEGS RCQFINLVTY
