ID   GRHL3_XENLA             Reviewed;         595 AA.
AC   Q5PPL8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Grainyhead-like protein 3 homolog;
DE   AltName: Full=Transcription factor CP2-like 4;
GN   Name=grhl3; Synonyms=tfcp2l4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor playing important roles in primary
CC       neurulation and in the differentiation of stratified epithelia of both
CC       ectodermal and endodermal origin. Binds directly to the consensus DNA
CC       sequence 5'-AACCGGTT-3' acting as an activator and repressor on
CC       distinct target genes. {ECO:0000250|UniProtKB:Q5FWH3,
CC       ECO:0000250|UniProtKB:Q8TE85}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6ISB3,
CC       ECO:0000250|UniProtKB:Q8TE85}.
CC   -!- MISCELLANEOUS: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal
CC       lack of redundancy despite their extensive sequence identity in the
CC       DNA-binding and protein dimerization domains and the fact that the core
CC       consensus DNA binding sites are identical. They have related but
CC       remarkably different functions during embryogenesis because of their
CC       differential spatiotemporal expression patterns during development.
CC       {ECO:0000250|UniProtKB:Q5FWH3}.
CC   -!- SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC087619; AAH87619.1; -; mRNA.
DR   RefSeq; NP_001088830.1; NM_001095361.1.
DR   AlphaFoldDB; Q5PPL8; -.
DR   SMR; Q5PPL8; -.
DR   DNASU; 496106; -.
DR   GeneID; 496106; -.
DR   KEGG; xla:496106; -.
DR   CTD; 496106; -.
DR   Xenbase; XB-GENE-919808; grhl3.L.
DR   OrthoDB; 286319at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 496106; Expressed in gastrula and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007604; CP2.
DR   Pfam; PF04516; CP2; 1.
DR   PROSITE; PS51968; GRH_CP2_DB; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..595
FT                   /note="Grainyhead-like protein 3 homolog"
FT                   /id="PRO_0000227999"
FT   DOMAIN          221..454
FT                   /note="Grh/CP2 DB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01313"
FT   REGION          29..92
FT                   /note="Transcription activation"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TE85"
FT   REGION          484..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   595 AA;  68411 MW;  29F9261BE1DBE8D9 CRC64;
     MSNELDYRPV MLLQNDISLQ KYSSPNDDDA WSKYLENPMT AATKAMMRAN GDDDGVAALS
     LLYDYYRVPK EKRIITQGST GRCDQVKRSC SEYESDISAY ESTQIMRYLN DNNSSTHEYS
     ETHKKNSYLS LDCLLNPSKL TLTSGKLDTN GHDDFMATTC DVYEKNSLNT LFDPIHVPSP
     QQRWQPDSTF KEDTPEPLIF NDILRRQAES TCSEDYIPGE ANRDFEYTLE SPKAIHIKSG
     ESPMAYLNKG QFYPVNLRTA EIRKCVHLTS NKVKSVVMVV FDNEKNPEEQ LKRWKHWHSR
     QPTAKQRVID VADYKENCNT VENIEEVAYN ALSFVWNVND EAKIFIGLNC LSTDFSSQKG
     VKGVPLNLQI DTYDFETGVK RLIHRAVCQI KIFCDKGAER KMRDEERKQF RRKGKCADQN
     NKDIKASVLP GYRGSDVTYL RPVTDMETHP VLFIPNIHYS NLQRCGVILQ SVADNSDRLS
     LKRSSQSFPK GLEAPPSKQQ TSEDSHRVLL YVRRETEEVF DALMLKTPDL KGLRNAISEK
     YELPEERIFR VYKKCKRGIL VNMDNNIIQH YSNHVAFLLD LTDVDGKIQV TLKEL