ID   GRHL3_XENTR             Reviewed;         594 AA.
AC   Q6GL65; Q28DS4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Grainyhead-like protein 3 homolog;
DE   AltName: Full=Transcription factor CP2-like 4;
GN   Name=grhl3; Synonyms=tfcp2l4; ORFNames=TGas117i15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor playing important roles in primary
CC       neurulation and in the differentiation of stratified epithelia of both
CC       ectodermal and endodermal origin. Binds directly to the consensus DNA
CC       sequence 5'-AACCGGTT-3' acting as an activator and repressor on
CC       distinct target genes. {ECO:0000250|UniProtKB:Q5FWH3,
CC       ECO:0000250|UniProtKB:Q8TE85}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6ISB3,
CC       ECO:0000250|UniProtKB:Q8TE85}.
CC   -!- MISCELLANEOUS: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal
CC       lack of redundancy despite their extensive sequence identity in the
CC       DNA-binding and protein dimerization domains and the fact that the core
CC       consensus DNA binding sites are identical. They have related but
CC       remarkably different functions during embryogenesis because of their
CC       differential spatiotemporal expression patterns during development.
CC       {ECO:0000250|UniProtKB:Q5FWH3}.
CC   -!- SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR848623; CAJ83942.1; -; mRNA.
DR   EMBL; BC074642; AAH74642.1; -; mRNA.
DR   RefSeq; NP_001005642.1; NM_001005642.1.
DR   AlphaFoldDB; Q6GL65; -.
DR   SMR; Q6GL65; -.
DR   STRING; 8364.ENSXETP00000060412; -.
DR   PaxDb; Q6GL65; -.
DR   DNASU; 448111; -.
DR   GeneID; 448111; -.
DR   KEGG; xtr:448111; -.
DR   CTD; 57822; -.
DR   Xenbase; XB-GENE-919797; grhl3.
DR   eggNOG; KOG4091; Eukaryota.
DR   HOGENOM; CLU_021156_1_1_1; -.
DR   InParanoid; Q6GL65; -.
DR   OrthoDB; 286319at2759; -.
DR   PhylomeDB; Q6GL65; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003899; Expressed in embryo and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR007604; CP2.
DR   Pfam; PF04516; CP2; 1.
DR   PROSITE; PS51968; GRH_CP2_DB; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..594
FT                   /note="Grainyhead-like protein 3 homolog"
FT                   /id="PRO_0000228000"
FT   DOMAIN          220..453
FT                   /note="Grh/CP2 DB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01313"
FT   REGION          25..75
FT                   /note="Transcription activation"
FT   REGION          28..91
FT                   /note="Transcription activation"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TE85"
FT   REGION          483..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  68264 MW;  67FA0F10EC8CC45C CRC64;
     MSNELDYRPV MLLQNDINLK YSSPNDDEAW SKYLENPMTA ATKAMMRANG DDDGVAALSL
     LYDYYRVPKE KRIITQGSTG RCDQVKRSCI EYDSDISTYD STQLMRFLND NNSSTHEYSE
     THKKNSYLSL DCLINPSKLP LSSGKLDNNA HDDFMATSCD VYEKNPLTTL FDPIHVPPPQ
     QRWQPDSTFK EDTPEPLIFN DILRSQAEST CSEDYIPGEA NRDFECTLES PKAIHIKSGE
     SPMAYLNKGQ FYPVNLRTAE TRKCVHLTSN KVKSVVMVVF DNEKNPEEQL KRWKHWHSRQ
     PTAKQRVIDV ADYKENCNTV ENIEEVAYNA LSFVWNINEE AKIFIGINCL STDFSSQKGV
     KGVPLNLQID TYDFETGVKR LIHRAVCQIK IFCDKGAERK MRDEERKQFR RKGKSADQNN
     KDIKASVLPG YRGSDFTYLR PVTDMETHPV LFIPNIHYSN LQRCGVVLQS AADNSDRLSL
     KRSSQSFPES FEAPPSKQQT NEDPQRVLLY VRRETEEVFD ALMLKTPDLK GLRNAISEKY
     ELPEERICRV YKKCKRGILV NMDNNIIQHY SNHVAFLLDL TDVDGKIQVT LKEL