ID   GRHLP_RUDPH             Reviewed;          94 AA.
AC   A0A0A7DNP6;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   04-MAR-2015, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Prepro-gonadotropin-releasing hormone-like protein {ECO:0000303|PubMed:26219580};
DE            Short=rp-GnRH {ECO:0000303|PubMed:26219580};
DE   Contains:
DE     RecName: Full=GnRH dodecapeptide {ECO:0000303|PubMed:26219580};
DE   Contains:
DE     RecName: Full=GnRH-associated peptide {ECO:0000303|PubMed:26219580};
DE              Short=GAP {ECO:0000303|PubMed:26219580};
DE   Flags: Precursor;
OS   Ruditapes philippinarum (Japanese littleneck clam) (Venerupis
OS   philippinarum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Venerida; Veneroidea; Veneridae; Ruditapes.
OX   NCBI_TaxID=129788 {ECO:0000312|EMBL:AIU92925.1};
RN   [1] {ECO:0000312|EMBL:AIU92925.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND PHYLOGENETIC
RP   ANALYSIS.
RX   PubMed=26219580; DOI=10.1016/j.cbpb.2015.07.005;
RA   Song Y., Miao J., Cai Y., Pan L.;
RT   "Molecular cloning, characterization, and expression analysis of a
RT   gonadotropin-releasing hormone-like cDNA in the clam, Ruditapes
RT   philippinarum.";
RL   Comp. Biochem. Physiol. 189:47-54(2015).
CC   -!- FUNCTION: Neuropeptide involved in reproduction. May be an important
CC       hormone in the regulation of gonadal maturation.
CC       {ECO:0000269|PubMed:26219580}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q17128}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the visceral ganglia at the gonadal
CC       early development stage in both sexes. Expressed significantly higher
CC       in the female gonad of early development stage (stage 1) than the
CC       indifference stage (stage 0). Males have higher expression in stage 1
CC       compared with stage 0. Expression levels decrease during the late
CC       development stage (stage 2) and ripe stage (stage 3). There are
CC       positive significant correlations between the levels of this protein
CC       and progesterone as well as this protein and testosterone throughout
CC       the gonadal maturation. {ECO:0000269|PubMed:26219580}.
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DR   EMBL; KF891317; AIU92925.1; -; mRNA.
DR   AlphaFoldDB; A0A0A7DNP6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..94
FT                   /note="Prepro-gonadotropin-releasing hormone-like protein"
FT                   /id="PRO_5002026334"
FT   PEPTIDE         22..33
FT                   /note="GnRH dodecapeptide"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434899"
FT   PEPTIDE         36..94
FT                   /note="GnRH-associated peptide"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434900"
FT   SITE            34..35
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   94 AA;  10730 MW;  BD3140A4C0117213 CRC64;
     MNACILLTTL VTMITIEKVQ GQSYHFSNGW NPGKRSMQEP VCHFRQDVQT LVLKLIEDEV
     YRMLSDPSCI GGVPTLRNFL KKDLAYTVPL DDKK