ID   GRIFN_DANRE             Reviewed;         139 AA.
AC   Q6DGJ1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Grifin;
DE   AltName: Full=DrGRIFIN;
DE   AltName: Full=Galectin-related inter-fiber protein;
GN   Name=grifin; ORFNames=zgc:92897;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, BETA-GALACTOSIDE-BINDING, DOMAIN, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=18448074; DOI=10.1016/j.bbrc.2008.04.078;
RA   Ahmed H., Vasta G.R.;
RT   "Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a
RT   functional carbohydrate-binding galectin.";
RL   Biochem. Biophys. Res. Commun. 371:350-355(2008).
CC   -!- FUNCTION: Binds lactose. {ECO:0000269|PubMed:18448074}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Localized to the lens of early embryos (48 hpf),
CC       particularly in lens fiber cells (at protein level). In the adult,
CC       expression is highest in the eye but is also present in oocytes, brain
CC       and intestine. {ECO:0000269|PubMed:18448074}.
CC   -!- DEVELOPMENTAL STAGE: Weakly expressed in embryos as early as 21 hpf,
CC       and strongly expressed at least up to 7 dpf.
CC       {ECO:0000269|PubMed:18448074}.
CC   -!- DOMAIN: The galectin domain, in contrast to the one in mammalian
CC       ortholog, is a functional carbohydrate-binding galectin.
CC       {ECO:0000269|PubMed:18448074}.
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DR   EMBL; BC076353; AAH76353.1; -; mRNA.
DR   RefSeq; NP_001003430.1; NM_001003430.1.
DR   AlphaFoldDB; Q6DGJ1; -.
DR   SMR; Q6DGJ1; -.
DR   STRING; 7955.ENSDARP00000049686; -.
DR   PaxDb; Q6DGJ1; -.
DR   Ensembl; ENSDART00000049687; ENSDARP00000049686; ENSDARG00000033382.
DR   Ensembl; ENSDART00000182662; ENSDARP00000145461; ENSDARG00000033382.
DR   GeneID; 445036; -.
DR   KEGG; dre:445036; -.
DR   CTD; 402635; -.
DR   ZFIN; ZDB-GENE-040801-163; grifin.
DR   eggNOG; KOG3587; Eukaryota.
DR   GeneTree; ENSGT00940000162164; -.
DR   HOGENOM; CLU_037794_3_0_1; -.
DR   InParanoid; Q6DGJ1; -.
DR   OMA; QYKHRQK; -.
DR   OrthoDB; 829777at2759; -.
DR   PhylomeDB; Q6DGJ1; -.
DR   TreeFam; TF315551; -.
DR   PRO; PR:Q6DGJ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000033382; Expressed in larva and 5 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030395; F:lactose binding; IDA:UniProtKB.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   InterPro; IPR030641; Grifin.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF21; PTHR11346:SF21; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   1: Evidence at protein level;
KW   Lectin; Reference proteome.
FT   CHAIN           1..139
FT                   /note="Grifin"
FT                   /id="PRO_0000315765"
FT   DOMAIN          5..134
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
SQ   SEQUENCE   139 AA;  16326 MW;  B237E1EF4F97658B CRC64;
     MTLRFEASCP DGLCPGWSVI LKGETPPEAS KFEINFLCDR DDRVAFHFNP RFTESDIICN
     SYMANRWGQE ERCNHFPLGV EEPFQIEIYS DNDHFHVYID KAKVMQYKHR VEDLKTITKL
     QVVNDVKISS LEITKKLFY