GRIFN_MOUSE
ID GRIFN_MOUSE Reviewed; 144 AA.
AC Q9D1U0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Grifin;
DE AltName: Full=Galectin-related inter-fiber protein;
GN Name=Grifin;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- DOMAIN: The galectin domain is atypical and does not bind beta-
CC galactoside sugars. {ECO:0000250}.
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DR EMBL; AK021365; BAB32388.1; -; mRNA.
DR EMBL; BC107323; AAI07324.1; -; mRNA.
DR EMBL; BC107324; AAI07325.1; -; mRNA.
DR CCDS; CCDS39357.1; -.
DR RefSeq; NP_084298.1; NM_030022.1.
DR AlphaFoldDB; Q9D1U0; -.
DR SMR; Q9D1U0; -.
DR BioGRID; 219082; 1.
DR STRING; 10090.ENSMUSP00000039263; -.
DR PhosphoSitePlus; Q9D1U0; -.
DR MaxQB; Q9D1U0; -.
DR PaxDb; Q9D1U0; -.
DR PRIDE; Q9D1U0; -.
DR ProteomicsDB; 269830; -.
DR Ensembl; ENSMUST00000042993; ENSMUSP00000039263; ENSMUSG00000036586.
DR GeneID; 77998; -.
DR KEGG; mmu:77998; -.
DR UCSC; uc009aht.1; mouse.
DR CTD; 402635; -.
DR MGI; MGI:1925248; Grifin.
DR VEuPathDB; HostDB:ENSMUSG00000036586; -.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000162164; -.
DR HOGENOM; CLU_037794_3_0_1; -.
DR InParanoid; Q9D1U0; -.
DR OMA; QYKHRQK; -.
DR OrthoDB; 829777at2759; -.
DR PhylomeDB; Q9D1U0; -.
DR TreeFam; TF315551; -.
DR BioGRID-ORCS; 77998; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q9D1U0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D1U0; protein.
DR Bgee; ENSMUSG00000036586; Expressed in epithelium of lens and 30 other tissues.
DR Genevisible; Q9D1U0; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd00070; GLECT; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR InterPro; IPR030641; Grifin.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR PANTHER; PTHR11346:SF21; PTHR11346:SF21; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR SMART; SM00908; Gal-bind_lectin; 1.
DR SMART; SM00276; GLECT; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 2: Evidence at transcript level;
KW Lectin; Phosphoprotein; Reference proteome.
FT CHAIN 1..144
FT /note="Grifin"
FT /id="PRO_0000315763"
FT DOMAIN 5..133
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O88644"
SQ SEQUENCE 144 AA; 15971 MW; 1D7CD73EAC4C6CEC CRC64;
MTLQFEAFCA GGLAPGWSLT VQGHADAGEE KFEINFLTDA GDIAFHVKPR FSSATVVGNA
FQGGRWGQEE VSSIFPLTLG EPFEMEVSAD AEHFHIYAQE QKVLQFPHRH RPLATITRVR
VLSEHRLAQV ELAKRSLSWG DGGY
