ID   GRIFN_RAT               Reviewed;         144 AA.
AC   O88644;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Grifin;
DE   AltName: Full=Galectin-related inter-fiber protein;
GN   Name=Grifin;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], LACK OF BETA-GALACTOSIDE-BINDING, SUBUNIT,
RP   DOMAIN, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=9786891; DOI=10.1074/jbc.273.44.28889;
RA   Ogden A.T., Nunes I., Ko K., Wu S., Hines C.S., Wang A.-F., Hegde R.S.,
RA   Lang R.A.;
RT   "GRIFIN, a novel lens-specific protein related to the galectin family.";
RL   J. Biol. Chem. 273:28889-28896(1998).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:9786891}.
CC   -!- TISSUE SPECIFICITY: Lens-specific. Located at the interface between
CC       lens fiber cells (at protein level). {ECO:0000269|PubMed:9786891}.
CC   -!- DEVELOPMENTAL STAGE: Increases during lens maturation (at protein
CC       level). {ECO:0000269|PubMed:9786891}.
CC   -!- DOMAIN: The galectin domain is atypical and does not bind beta-
CC       galactoside sugars. {ECO:0000269|PubMed:9786891}.
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DR   EMBL; AF082160; AAC71765.1; -; mRNA.
DR   RefSeq; NP_476535.1; NM_057187.2.
DR   AlphaFoldDB; O88644; -.
DR   SMR; O88644; -.
DR   BioGRID; 250681; 1.
DR   STRING; 10116.ENSRNOP00000001686; -.
DR   iPTMnet; O88644; -.
DR   PhosphoSitePlus; O88644; -.
DR   PaxDb; O88644; -.
DR   GeneID; 117130; -.
DR   KEGG; rno:117130; -.
DR   CTD; 402635; -.
DR   RGD; 71055; Grifin.
DR   eggNOG; KOG3587; Eukaryota.
DR   InParanoid; O88644; -.
DR   OrthoDB; 829777at2759; -.
DR   PhylomeDB; O88644; -.
DR   PRO; PR:O88644; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   InterPro; IPR030641; Grifin.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF21; PTHR11346:SF21; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   1: Evidence at protein level;
KW   Lectin; Phosphoprotein; Reference proteome.
FT   CHAIN           1..144
FT                   /note="Grifin"
FT                   /id="PRO_0000315764"
FT   DOMAIN          5..133
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   144 AA;  15839 MW;  C534DE2C203AC518 CRC64;
     MALQFEAFCA GGLAPGWSLT VQGHADAGED KFEINFLTDA GDIAFHVKPR FSSATVVGNA
     FQGGRWGQEE VSSVFPLTLG EPFEVEVSAD TEHFHIYAQE QKVLQFPHRH RPLATITRVR
     VLSDHQLAQV ELAKRGLSWG DGGY