ID   GRIH_STRGG              Reviewed;         396 AA.
AC   B1VTI7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=3-amino-4-hydroxybenzoic acid synthase;
DE            Short=3,4-AHBA synthase;
DE            EC=4.1.99.20 {ECO:0000250|UniProtKB:A0JC76};
GN   Name=griH; OrderedLocusNames=SGR_4248;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Catalyzes the cyclization of 2-amino-4,5-dihydroxy-6-one-
CC       heptanoic acid-7-phosphate to yield 3-amino-4-hydroxybenzoic acid (3,4-
CC       AHBA). {ECO:0000250|UniProtKB:A0JC76}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-
CC         amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate;
CC         Xref=Rhea:RHEA:26317, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58898, ChEBI:CHEBI:60005;
CC         EC=4.1.99.20; Evidence={ECO:0000250|UniProtKB:A0JC76};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000250|UniProtKB:A0JC76};
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:A0JC76}.
CC   -!- SIMILARITY: Belongs to the archaeal-type DHQ synthase family. GriH
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AP009493; BAG21077.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1VTI7; -.
DR   STRING; 455632.SGR_4248; -.
DR   EnsemblBacteria; BAG21077; BAG21077; SGR_4248.
DR   KEGG; sgr:SGR_4248; -.
DR   eggNOG; COG1465; Bacteria.
DR   HOGENOM; CLU_056379_1_0_11; -.
DR   OMA; HFGMAIK; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002812; DHQ_synth.
DR   PANTHER; PTHR33563; PTHR33563; 1.
DR   Pfam; PF01959; DHQS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Manganese.
FT   CHAIN           1..396
FT                   /note="3-amino-4-hydroxybenzoic acid synthase"
FT                   /id="PRO_0000361908"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  42438 MW;  C61B33EDA34C1201 CRC64;
     MSSSPSPSPS SSSSSSASSS ASSSPSSSSK LTWLDIRSVG EARAAIVQEA LHHRVEALVA
     DDPAHLADLP PTVAKVLLVV GKQIPEEFGE ATVVVVDPSK HGVTPAELAL KHPEIEFGRF
     VEIIDAPTLE DACESSRTEK WSVLLFRDPT KIPLEIVIAA AARASGSMVT IAQDLEEAEI
     LFGVLEHGSD GVMMAPKTVG DAAELKRIAE AGIPNLNLTE LRVVETSHIG MGERACVDTT
     THFGEDEGIL VGSHSKGMIL CVSETHPLPY MPTRPFRVNA GAIHSYTLGR DERTNYLSEL
     KTGSKLTAVD IKGNTRLVTV GRVKIETRPL ISIDAEAPDG RRVNLILQDD WHVRVLGPGG
     TVLNSTELKP GDTVLGYLPV EDRHVGYPIN EFCLEK