ID   GRII_STRGG              Reviewed;         274 AA.
AC   B1VTI8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase;
DE            EC=4.1.2.56;
GN   Name=griI; OrderedLocusNames=SGR_4249;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: catalyzes aldol condensation between L-aspartate-4-
CC       semialdehyde (ASA) and dihydroxyacetone phosphate (DHAP), to form 2-
CC       amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate =
CC         dihydroxyacetone phosphate + L-aspartate 4-semialdehyde;
CC         Xref=Rhea:RHEA:26313, ChEBI:CHEBI:57642, ChEBI:CHEBI:58898,
CC         ChEBI:CHEBI:537519; EC=4.1.2.56;
CC   -!- SUBUNIT: Homodecamer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. GriI subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP009493; BAG21078.1; -; Genomic_DNA.
DR   RefSeq; WP_012380462.1; NC_010572.1.
DR   AlphaFoldDB; B1VTI8; -.
DR   SMR; B1VTI8; -.
DR   STRING; 455632.SGR_4249; -.
DR   EnsemblBacteria; BAG21078; BAG21078; SGR_4249.
DR   GeneID; 6213293; -.
DR   KEGG; sgr:SGR_4249; -.
DR   eggNOG; COG1830; Bacteria.
DR   HOGENOM; CLU_057069_2_0_11; -.
DR   OMA; CEYWGMP; -.
DR   OrthoDB; 1560751at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:InterPro.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00958; DhnA; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR041720; FbaB-like.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF038992; Aldolase_Ia; 1.
DR   SMART; SM01133; DeoC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase.
FT   CHAIN           1..274
FT                   /note="2-amino-4,5-dihydroxy-6-oxo-7-
FT                   (phosphonooxy)heptanoate synthase"
FT                   /id="PRO_0000361268"
SQ   SEQUENCE   274 AA;  28851 MW;  88D038603BE5DBDF CRC64;
     MAPNAPFARS LRLQRLHHHD PDRLFIVPLD HSITDGPLSR AHRLDPLVGE LASHHVDGIV
     LHKGSLRHVD PEWFTRTSLI VHLSASTVHA PDPNAKYLVS SVEESLRMGA DAVSVHVNLG
     SEGERHQIAD MAAVAEACDR WNVPLLAMMY PRGPKIDDPR DPALVAHAVQ VAVDLGADLV
     KTLYVGSVAA MAEITAASPV PVVVVGGPRD SDESRILAYV DDALRGGAAG VAMGRNVFQA
     PDPGAMADKL SDLIHNSGTR GAARAPAGAA AGAA