ID   GRIN3_HUMAN             Reviewed;         776 AA.
AC   Q6ZVF9; Q8IVE4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=G protein-regulated inducer of neurite outgrowth 3;
DE            Short=GRIN3;
GN   Name=GPRIN3; Synonyms=KIAA2027;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-446.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in neurite outgrowth. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC23123.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB095947; BAC23123.2; ALT_INIT; mRNA.
DR   EMBL; AK124616; BAC85902.1; -; mRNA.
DR   CCDS; CCDS34030.1; -.
DR   RefSeq; NP_938022.2; NM_198281.2.
DR   RefSeq; XP_005262993.1; XM_005262936.3.
DR   RefSeq; XP_005262994.1; XM_005262937.4.
DR   RefSeq; XP_016863532.1; XM_017008043.1.
DR   RefSeq; XP_016863533.1; XM_017008044.1.
DR   AlphaFoldDB; Q6ZVF9; -.
DR   BioGRID; 130131; 38.
DR   IntAct; Q6ZVF9; 3.
DR   MINT; Q6ZVF9; -.
DR   STRING; 9606.ENSP00000476603; -.
DR   iPTMnet; Q6ZVF9; -.
DR   PhosphoSitePlus; Q6ZVF9; -.
DR   SwissPalm; Q6ZVF9; -.
DR   BioMuta; GPRIN3; -.
DR   DMDM; 115502242; -.
DR   jPOST; Q6ZVF9; -.
DR   MassIVE; Q6ZVF9; -.
DR   MaxQB; Q6ZVF9; -.
DR   PaxDb; Q6ZVF9; -.
DR   PeptideAtlas; Q6ZVF9; -.
DR   PRIDE; Q6ZVF9; -.
DR   ProteomicsDB; 68413; -.
DR   Antibodypedia; 44913; 133 antibodies from 29 providers.
DR   DNASU; 285513; -.
DR   Ensembl; ENST00000333209.4; ENSP00000328672.3; ENSG00000185477.5.
DR   Ensembl; ENST00000609438.2; ENSP00000476603.1; ENSG00000185477.5.
DR   GeneID; 285513; -.
DR   KEGG; hsa:285513; -.
DR   MANE-Select; ENST00000609438.2; ENSP00000476603.1; NM_198281.3; NP_938022.2.
DR   UCSC; uc003hsm.2; human.
DR   CTD; 285513; -.
DR   DisGeNET; 285513; -.
DR   GeneCards; GPRIN3; -.
DR   HGNC; HGNC:27733; GPRIN3.
DR   HPA; ENSG00000185477; Tissue enhanced (brain).
DR   MIM; 611241; gene.
DR   neXtProt; NX_Q6ZVF9; -.
DR   OpenTargets; ENSG00000185477; -.
DR   PharmGKB; PA162390203; -.
DR   VEuPathDB; HostDB:ENSG00000185477; -.
DR   eggNOG; ENOG502QTMW; Eukaryota.
DR   GeneTree; ENSGT00570000079168; -.
DR   HOGENOM; CLU_020316_0_0_1; -.
DR   InParanoid; Q6ZVF9; -.
DR   OMA; GRQHNVF; -.
DR   OrthoDB; 612273at2759; -.
DR   PhylomeDB; Q6ZVF9; -.
DR   TreeFam; TF337047; -.
DR   PathwayCommons; Q6ZVF9; -.
DR   BioGRID-ORCS; 285513; 9 hits in 1066 CRISPR screens.
DR   ChiTaRS; GPRIN3; human.
DR   GenomeRNAi; 285513; -.
DR   Pharos; Q6ZVF9; Tbio.
DR   PRO; PR:Q6ZVF9; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q6ZVF9; protein.
DR   Bgee; ENSG00000185477; Expressed in epithelial cell of pancreas and 151 other tissues.
DR   Genevisible; Q6ZVF9; HS.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR   InterPro; IPR026646; GPRIN2-like/GPRIN3.
DR   InterPro; IPR032745; GRIN_C.
DR   PANTHER; PTHR15718; PTHR15718; 1.
DR   Pfam; PF15235; GRIN_C; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..776
FT                   /note="G protein-regulated inducer of neurite outgrowth 3"
FT                   /id="PRO_0000251950"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..748
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         332
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BWS5"
FT   MOD_RES         365
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BWS5"
FT   VARIANT         39
FT                   /note="L -> V (in dbSNP:rs11734353)"
FT                   /id="VAR_051019"
FT   VARIANT         378
FT                   /note="A -> V (in dbSNP:rs6811370)"
FT                   /id="VAR_051020"
FT   VARIANT         382
FT                   /note="S -> P (in dbSNP:rs28622301)"
FT                   /id="VAR_051021"
FT   VARIANT         390
FT                   /note="P -> S (in dbSNP:rs11733183)"
FT                   /id="VAR_051022"
FT   VARIANT         446
FT                   /note="V -> A (in dbSNP:rs7653897)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_051023"
FT   VARIANT         746
FT                   /note="R -> K (in dbSNP:rs17015286)"
FT                   /id="VAR_051024"
FT   CONFLICT        363
FT                   /note="H -> R (in Ref. 2; BAC85902)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   776 AA;  82439 MW;  54C7E7CF69F1CD1B CRC64;
     MGTVPDPLRS AKTSLIAASG KEDDLGEPQA ASPRHRPALL CKNANGFSGA PAEPDLSPRA
     AAEALMQVCE HETTQPDMSS PGVFNEVQKA PATFNSPGNP QLPGSSQPAA SAPSSAAGRD
     LIHTPLTMPA NQHTCQSIPG DQPNAITSSM PEDSLMRSQR TSNREQPEKP SCPVGGVLSS
     SKDQVSCEFP SPETIQGTVQ TPVTAARVVS HSSSPVGGPE GERQGAICDS EMRSCKPLTR
     ESGCSENKQP SVTASGPQGT TSVTPQPTPL TSEPSACPPG PEKVPLPAQR QMSRFKEAST
     MTNQAESEIK EVPSRAWQDA EVQAVASVES RSVSTSPSIL TAFLKESRAP EHFEQEQLRV
     ICHSSGSHTL ELSDSTLAPQ ESSQCPGIMP QVHIQAAAAE STAFQRENKL ASLPGGVLKT
     SSINLVSSNA QHTCKEDGRL AGMTPVREES TAKKLAGTNS SSLKATAIDQ ISISACSQAE
     TSYGLGKFET RPSEFAEKTT NGHKTDPDCK LSDSCGSISK ADHSGSLDPT NKGDAREKKP
     ASPQVVKEKE STGTDTSDAK TLLLNPKSQE SGGTESAANP TPSPIRKNQE STLEENRQTK
     TATSLSLPSD PMGDSSPGSG KKTPSRSVKA SPRRPSRVSE FLKEQKLNVT AAAAQVGLTP
     GDKKKQLGAD SKLQLKQSKR VRDVVWDEQG MTWEVYGASL DAESLGIAIQ NHLQRQIREH
     EKLIKTQNSQ TRRSISSDTS SNKKLRGRQH SVFQSMLQNF RRPNCCVRPA PSSVLD