GRIN3_MOUSE
ID GRIN3_MOUSE Reviewed; 763 AA.
AC Q8BWS5; Q69Z30;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=G protein-regulated inducer of neurite outgrowth 3;
DE Short=GRIN3;
GN Name=Gprin3; Synonyms=Kiaa2027;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION.
RX PubMed=15488195; DOI=10.1016/s0076-6879(04)90029-8;
RA Iida N., Kozasa T.;
RT "Identification and biochemical analysis of GRIN1 and GRIN2.";
RL Methods Enzymol. 390:475-483(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323 AND SER-359, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in neurite outgrowth. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32614.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173336; BAD32614.1; ALT_INIT; mRNA.
DR EMBL; AK050148; BAC34093.1; -; mRNA.
DR CCDS; CCDS20199.1; -.
DR RefSeq; NP_899006.1; NM_183183.2.
DR AlphaFoldDB; Q8BWS5; -.
DR BioGRID; 232514; 1.
DR IntAct; Q8BWS5; 2.
DR MINT; Q8BWS5; -.
DR STRING; 10090.ENSMUSP00000051805; -.
DR iPTMnet; Q8BWS5; -.
DR PhosphoSitePlus; Q8BWS5; -.
DR EPD; Q8BWS5; -.
DR MaxQB; Q8BWS5; -.
DR PaxDb; Q8BWS5; -.
DR PRIDE; Q8BWS5; -.
DR ProteomicsDB; 269632; -.
DR Antibodypedia; 44913; 133 antibodies from 29 providers.
DR DNASU; 243385; -.
DR Ensembl; ENSMUST00000051065; ENSMUSP00000051805; ENSMUSG00000045441.
DR GeneID; 243385; -.
DR KEGG; mmu:243385; -.
DR UCSC; uc009cdk.1; mouse.
DR CTD; 285513; -.
DR MGI; MGI:1924785; Gprin3.
DR VEuPathDB; HostDB:ENSMUSG00000045441; -.
DR eggNOG; ENOG502QTMW; Eukaryota.
DR GeneTree; ENSGT00570000079168; -.
DR HOGENOM; CLU_020316_0_0_1; -.
DR InParanoid; Q8BWS5; -.
DR OMA; GRQHNVF; -.
DR OrthoDB; 612273at2759; -.
DR PhylomeDB; Q8BWS5; -.
DR TreeFam; TF337047; -.
DR BioGRID-ORCS; 243385; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8BWS5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BWS5; protein.
DR Bgee; ENSMUSG00000045441; Expressed in caudate-putamen and 141 other tissues.
DR ExpressionAtlas; Q8BWS5; baseline and differential.
DR Genevisible; Q8BWS5; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR InterPro; IPR026646; GPRIN2-like/GPRIN3.
DR InterPro; IPR032745; GRIN_C.
DR PANTHER; PTHR15718; PTHR15718; 1.
DR Pfam; PF15235; GRIN_C; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..763
FT /note="G protein-regulated inducer of neurite outgrowth 3"
FT /id="PRO_0000251951"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 359
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 763 AA; 80485 MW; 34972AE1BF6CA09B CRC64;
MGTVPDPLRV TKASIVAASG KEESRGESQS VSPQPAQPDN NASGIGNVPA ELSLQLSAAA
QALMQACVSE SSQQDMASPG VFSEGEPVSP KQKTPDDFLL HGSKESAAPG LNATAQKELI
SAPCLISVVQ HTHHAIQRDA PNTSTCAVPE GSLVKSEANS NGENPEKPGC PARVTCCSSK
NQEGLCDFPS PENSQGILQT PDIASPSADR PEGEGQKVIN NITAVSSEPP VREGCSENKQ
PSATALNTTA ERSENPPPSH LTSKGATCSS EARQALLPAQ YPVSRFKEAS TMTCQAESGA
KEVSGRAWQD AEVQAVASVE SRSVSTSPSI LPAYLKENPA PELENGQEQL RVICHGKGSG
NHLLELSNSM VDSQESRQCP SIVPQVHIQA ATATPAAFKG GCKPANQPAE GLKSPLIHVT
SSQNTETEED LRLSASKEAT SRQPEGTNPD FQKANAIGQI SLPAGSQAEI NQGLWNSGPR
EPEIVVKTAK DHKAESSCKP SNSGGGANKD YPPESLDPTD KKGAKDKKPA SPLIVKDHAP
GATSTLDAKT LLLNPKSQVK EGEGPEVSPA PSPGRKSQQN TLEELRQPKT VMSLSLPSDG
TGDSSPGSGK RTPSLSVKAS PRRGSRVSEF LKELSVTAAA AQVGLTPGEK KKQLGADSKL
HLKQSKRVRD VVWDDQGMTW EVYGASLDPE SLGVAIQNHL QRQIREHEKI VKTQSGQTRR
SISSDSSSSK KLKGRQHGVL QSMLQNFRRP NCCVRPAPSS VLD
