GRIP4_ARATH
ID GRIP4_ARATH Reviewed; 377 AA.
AC Q9LJP1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=GDSL esterase/lipase 4;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase 4;
DE Flags: Precursor;
GN Name=GLIP4; OrderedLocusNames=At3g14225; ORFNames=MLE3.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=16126835; DOI=10.1105/tpc.105.034819;
RA Oh I.S., Park A.R., Bae M.S., Kwon S.J., Kim Y.S., Lee J.E., Kang N.Y.,
RA Lee S., Cheong H., Park O.K.;
RT "Secretome analysis reveals an Arabidopsis lipase involved in defense
RT against Alternaria brassicicola.";
RL Plant Cell 17:2832-2847(2005).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01436.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP000416; BAB01436.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB022220; BAB01436.1; JOINED; Genomic_DNA.
DR EMBL; CP002686; AEE75489.1; -; Genomic_DNA.
DR RefSeq; NP_001325624.1; NM_001338115.1.
DR RefSeq; NP_188039.1; NM_112280.1.
DR AlphaFoldDB; Q9LJP1; -.
DR SMR; Q9LJP1; -.
DR STRING; 3702.AT3G14225.1; -.
DR PaxDb; Q9LJP1; -.
DR EnsemblPlants; AT3G14225.1; AT3G14225.1; AT3G14225.
DR GeneID; 820641; -.
DR Gramene; AT3G14225.1; AT3G14225.1; AT3G14225.
DR KEGG; ath:AT3G14225; -.
DR Araport; AT3G14225; -.
DR TAIR; locus:2090785; AT3G14225.
DR eggNOG; ENOG502QQ4G; Eukaryota.
DR HOGENOM; CLU_015101_0_2_1; -.
DR InParanoid; Q9LJP1; -.
DR OrthoDB; 704138at2759; -.
DR PhylomeDB; Q9LJP1; -.
DR BioCyc; ARA:AT3G14225-MON; -.
DR PRO; PR:Q9LJP1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJP1; baseline and differential.
DR Genevisible; Q9LJP1; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; ISS:TAIR.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR044552; GLIP1-5/GLL25.
DR InterPro; IPR008265; Lipase_GDSL_AS.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR PANTHER; PTHR45966; PTHR45966; 1.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR PROSITE; PS01098; LIPASE_GDSL_SER; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..377
FT /note="GDSL esterase/lipase 4"
FT /id="PRO_0000367337"
FT ACT_SITE 44
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 342
FT /evidence="ECO:0000250"
FT ACT_SITE 345
FT /evidence="ECO:0000250"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 42029 MW; B151B808FB7B0CFE CRC64;
MASPRFNSII IILFICTISL SIVSISCKED LKTNQAALFA FGDSLFEAGN NNYFDSISSF
RSNFWPYGKT TFKFPTGRVS DGRIMIDFIA EYAWLPLIPP NLQPGYSNSQ LTYGLNFATT
AAGVFAGTFP GSVTNLSKDL GTQLNNFKNV EKTLRSNLGD AEARRVISKA VYLFHIGAND
YQYPFFANTS TFSNTTKERF IDFVIGNTTT VIEELYKLGA RKFGFLSLGP FGCTPSALII
NSTKIGSCFE PVTELINLHN QEFPKVLRRL ERRLSGFKYA LHDFHTSLSQ RINNPSRYGF
KEGEMACCGS GPLRGINTCG FRNGPSQGYK LCENADDYVF FDPSHLTETA HQQIAELIWS
GPPNVTAPYN LKTLFRL
