ID   GRL1A_PONAB             Reviewed;         367 AA.
AC   Q5REC6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=DNA-directed RNA polymerase II subunit GRINL1A;
DE   AltName: Full=DNA-directed RNA polymerase II subunit M;
DE   AltName: Full=Glutamate receptor-like protein 1A;
GN   Name=POLR2M; Synonyms=GRINL1A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to be stable component of the Pol II(G) complex form
CC       of RNA polymerase II. Pol II synthesizes mRNA precursors and many
CC       functional non-coding RNAs and is the central component of the basal
CC       RNA polymerase II transcription machinery. May play a role in Mediator-
CC       dependent regulation of transcription activation. In vitro, acts as
CC       negative regulator of transcriptional activation; this repression is
CC       relieved by the Mediator complex, which restores Pol II(G) activator-
CC       dependent transcription to a level equivalent to that of Pol II (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Pol II(G) complex, which contains the RNA
CC       polymerase II (Pol II) core complex subunits and POLR2M and appears to
CC       be an abundant form of Pol II. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GRINL1 family. {ECO:0000305}.
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DR   EMBL; CR857605; CAH89881.1; -; mRNA.
DR   RefSeq; NP_001124877.1; NM_001131405.1.
DR   AlphaFoldDB; Q5REC6; -.
DR   SMR; Q5REC6; -.
DR   PRIDE; Q5REC6; -.
DR   GeneID; 100171742; -.
DR   KEGG; pon:100171742; -.
DR   CTD; 81488; -.
DR   InParanoid; Q5REC6; -.
DR   OrthoDB; 1227717at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016591; C:RNA polymerase II, holoenzyme; ISS:UniProtKB.
DR   InterPro; IPR026213; GRINL1.
DR   Pfam; PF15328; GCOM2; 1.
DR   PRINTS; PR02085; POLR2GRINL1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW   Transcription.
FT   CHAIN           1..367
FT                   /note="DNA-directed RNA polymerase II subunit GRINL1A"
FT                   /id="PRO_0000326231"
FT   REGION          117..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          15..40
FT                   /evidence="ECO:0000255"
FT   COILED          300..329
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        117..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  41797 MW;  B33FA24B8791CAD3 CRC64;
     MCSLPRGFEP QVPEDLERRS LAELREMLKR QERLLRNEKF ICKLPDKGKK IFDSFAKLKA
     AIAECEEVRR KSELCHPVSL DCKLRQKAIA EVDVGTDKAQ NSDPILDTSS LVPGCSSVDN
     IKSSQTSQNQ GLGRPTLEGD EETSEVEYSV NKGPASSNRD RVPPSSEASE YHLQHRVSSQ
     AEDTSSSFDN LFIDRLQRIT IADQGEQQSE NASTKNLTGL SSGTQKKPHY MEVLEMRAKN
     PVPQLHKFKT NVLPFRQNDS SSHCQKSRSP ISSEERRRRD KQHLDDITAA RLLPLHHMPT
     QLLSIEESLA LQKQRKQKYE EMQAKLAAQK LAERLNIKMR SYNPEGESSG RYREVRDEDD
     DWSSDEF