GRLC_DICDI
ID GRLC_DICDI Reviewed; 800 AA.
AC Q54SH7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Metabotropic glutamate receptor-like protein C;
DE Flags: Precursor;
GN Name=grlC; ORFNames=DDB_G0282461;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66090.1; -; Genomic_DNA.
DR RefSeq; XP_640062.1; XM_634970.1.
DR AlphaFoldDB; Q54SH7; -.
DR SMR; Q54SH7; -.
DR PaxDb; Q54SH7; -.
DR EnsemblProtists; EAL66090; EAL66090; DDB_G0282461.
DR GeneID; 8623590; -.
DR KEGG; ddi:DDB_G0282461; -.
DR dictyBase; DDB_G0282461; grlC.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q54SH7; -.
DR OMA; CTAGLFI; -.
DR PhylomeDB; Q54SH7; -.
DR PRO; PR:Q54SH7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..800
FT /note="Metabotropic glutamate receptor-like protein C"
FT /id="PRO_0000370348"
FT TOPO_DOM 22..392
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..463
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 485..499
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 521..551
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608..616
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 617..637
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 638..800
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 658..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89595 MW; 0627FFE517FCAA70 CRC64;
MKMKIIFLIL ILIFSINIIK CDKEFKMLTL LTAQVDDLGF NNMINQGRIE VAKGMNIEDS
RLLVVEGFNE TFKHLLPIVQ NDDIDLVICS SSGHLQACRA IAEMYINSTT IKTQFLVRGS
SSPTRNLIYI SYNYASANYI SGYFAALFSK TGKIGFVSPG QAANNNDSFV YAFWVGARQV
NPDIKFYYYN IGNYLDVDKT VAATNDLLDM GCDVVGNTLD DFSTGDASIA RGFPAIGTNG
FPQRHVYGEN VIYSYSYNWT KFFLPIAESV KSGNTNNSQW YADFDFDENK NFYHLDYGFE
VNQSILDKMN TEIDYLKSTD RMSHPYYCNE LIPQYAKENN LKLANVTGIT LPIGCVTHQT
FLSINKPFPG MTYLGNYKIK LVEVEFSQSL QYGFSITTGV LIAITIIMML GIVRYKSTPS
IRSASPIFLN FILAGGIIVY IGIIVWVGPA NDHQCNARLW LVTLGFSTLI GSLVVKNFRI
WLIFDNPELK SISITNYQLF PWVGACLVIN IILMSILTSV GDLREIDAQG IDSLGKYEFM
KVCKMNSSGA STLYTILAYF AALLLVGVFV SWKIRIVDIQ EFNESKAIAN TLYAISFCLF
VIVPLMISPQ DKQSETIVLC TAGLFITTAA LLIIFTPKFW RVFTLGDGGT NDMFRKKQSN
VATARAESSK SSSGPKLNRR GNLVSDDFTD TETSISEKKV NVVAGAVLAE FTDDTISEFD
DNNIEQDNDN DNDNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNTNTSQP
NDEKVEEKQQ NDTEEEDKNQ
