GRLD_DICDI
ID GRLD_DICDI Reviewed; 791 AA.
AC Q54L53;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Metabotropic glutamate receptor-like protein D;
DE Flags: Precursor;
GN Name=grlD; ORFNames=DDB_G0286895;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increasingly expressed from early aggregation.
CC {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000091; EAL64005.1; -; Genomic_DNA.
DR RefSeq; XP_637510.1; XM_632418.1.
DR AlphaFoldDB; Q54L53; -.
DR SMR; Q54L53; -.
DR STRING; 44689.DDB0231972; -.
DR PaxDb; Q54L53; -.
DR EnsemblProtists; EAL64005; EAL64005; DDB_G0286895.
DR GeneID; 8625849; -.
DR KEGG; ddi:DDB_G0286895; -.
DR dictyBase; DDB_G0286895; grlD.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q54L53; -.
DR OMA; NTHAIRS; -.
DR PhylomeDB; Q54L53; -.
DR PRO; PR:Q54L53; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:1903665; P:negative regulation of asexual reproduction; IMP:dictyBase.
DR GO; GO:0110094; P:polyphosphate-mediated signaling; IMP:dictyBase.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..791
FT /note="Metabotropic glutamate receptor-like protein D"
FT /id="PRO_0000370349"
FT TOPO_DOM 23..390
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..424
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..453
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..495
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 517..550
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 551..571
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..585
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 607..615
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 616..636
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 637..791
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 664..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 752..781
FT /evidence="ECO:0000255"
FT COMPBIAS 664..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 791 AA; 87715 MW; E9C63D008FF69999 CRC64;
MKINSFLIIL ILLFISIKNS NGEPEKKFKL ITLLAAHVQD LGFNNMVNRG HVEVSKAMKL
EDSQAIVVVG YNDTIRILAP LVAVGDVDLV ICSSQDHAQA CRELATKYKG SSIKTQFLVR
GSGEATSNLI TYSYNYANAN YISGYFAGLY TKTNKIGFLS PGAIDNNNDS FVYAFWYGAK
RANPDISFYY YNIGNYLNPD KTVAATKDLL DMGCDMVADT LNDFSTGNTL IANNRKTAMG
TSGFPQRDVY GEDVIYSYNY NWFKLFYPVA QSVYSGNTNN TNWYADFNLN ETISFFGLSF
SFTVPNETLT KFYEELDYLK RTPRLSHPYF CNDLMYEYAK KNHLTMSTND STHCLANSQF
TRINAPFPGM TWLGNYEITL TEVYQSRPIQ IAISSISSFF IVTVLVMMGL VVRFRKNPSI
RSASPIFLNF ILFGALIIYV GIIIWSSSIN SASCNAQFWL VTLGFTTLIG SLVVKNVRIW
LIFDNPELKL VKITNLQLVP WVGVCLVINI ILMSILTSVG DLREVNAQGI DSLGKYEFMR
ICKMNSSGAS TLYTILAYFA ALLLIGVFVS WKIRIVDILE FNESKAIANT LYAISFCLFV
IVPLMISPQD KQSEKIILCI AGLFIVTAAV LIIFVPKFYR VYIFGSGGTS DMFYKKKKQS
PVATARAEST SKGSSGGGAG SGGATGGSGV KTNKRGNLVS GDFSDDTESS LSEPNKPVKV
VAGAVLAEFT DDTISDLDNI DQPIEIITEN GQDSNNNNNN EENKDNNIEN NKISEEIKEN
LKNEENNDGD N
