GRLG_DICDI
ID GRLG_DICDI Reviewed; 772 AA.
AC Q75JP4; Q559M1;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Metabotropic glutamate receptor-like protein G;
DE Flags: Precursor;
GN Name=grlG; ORFNames=DDB_G0272244;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71274.1; -; Genomic_DNA.
DR RefSeq; XP_645313.1; XM_640221.1.
DR AlphaFoldDB; Q75JP4; -.
DR SMR; Q75JP4; -.
DR PaxDb; Q75JP4; -.
DR EnsemblProtists; EAL71274; EAL71274; DDB_G0272244.
DR GeneID; 8618479; -.
DR KEGG; ddi:DDB_G0272244; -.
DR dictyBase; DDB_G0272244; far2.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q75JP4; -.
DR OMA; INEGMIN; -.
DR PhylomeDB; Q75JP4; -.
DR PRO; PR:Q75JP4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..772
FT /note="Metabotropic glutamate receptor-like protein G"
FT /id="PRO_0000370351"
FT TOPO_DOM 24..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..463
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 485..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..521
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 522..551
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608..616
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 617..637
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 638..772
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 664..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 772 AA; 86338 MW; 57F80437D527CE92 CRC64;
MKKIIFLVLF LIFIFKDIKS SYGVDLVNFK MITLLSNNFN DLGFNNMLNQ GKVNVEKQLG
ITDTKVYIVD GYNDTKALLL PMVQNEDVDF VMCTSLGHVE ACKEIAKMYE GSLTIKTQFM
VRGSSNATSN LLQVTYNYAS INYISGVFAG LYTKTNKIGF LSPGLLGGSA DCFVYAYWLG
AKQINPKIEF YYYNIGAFLN SDKTTRATAE LLDMGCDVIG DTLDDFSAGN TVISRGFKAL
GTNGFPQREV YGENVVFSYS YNWTKIFLPI VKNALVKGKP KNNYADFNID PTLNFYDISY
GFDVPQDTKT KINDTISYLK STPRAIHPTN CNDLMLKYAE KWNLTMSTTY DRTKCIAGSN
FFFINEPFPG MTYFGYYNIT NTQVKFSPSI QIGVSIVSGV LIAIVLLSMV GVYKYRASSS
IRSASPIFLI FILFGALIVF GGIILWVSEL NDHVCNGRLW MVTLGFSTLI GSLVVKNFRI
WLIFDNPELK TVKITNYQLY PWVACCLVIN IILMSILTSL GDLREVDATG IDSLGKYEFL
KICKMNNSGA SVLYTILAYF GALLLTGVFV SWKIRIVDIE EFNESRAIAH TLYAISFCLF
VIVPLMISPL EKQSETIILS VAGLFITTAA VLIIFLPKFY RVYEYGEEGT NEMFKSKKSS
NIATARAESH KSSNSGNHRT NRRGNLVSGD FTDDSESSVI EPNQEVADVT SGAVLADFTE
ESVSEIDENE KNHNDEIELP EINQSEQQNS EIEQPPPPPP PQQIEPDEKN QD
