GRLL_DICDI
ID GRLL_DICDI Reviewed; 708 AA.
AC Q54U89;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Metabotropic glutamate receptor-like protein L;
DE Flags: Precursor;
GN Name=far1; Synonyms=grlL; ORFNames=DDB_G0281211;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain
CC infection and up-regulated by Pseudomonas aeruginosa, PA14 strain
CC infection. {ECO:0000269|PubMed:18590548}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000040; EAL66902.1; -; Genomic_DNA.
DR RefSeq; XP_640887.1; XM_635795.1.
DR AlphaFoldDB; Q54U89; -.
DR SMR; Q54U89; -.
DR STRING; 44689.DDB0231989; -.
DR PaxDb; Q54U89; -.
DR ABCD; Q54U89; 2 sequenced antibodies.
DR EnsemblProtists; EAL66902; EAL66902; DDB_G0281211.
DR GeneID; 8622944; -.
DR KEGG; ddi:DDB_G0281211; -.
DR dictyBase; DDB_G0281211; far1.
DR eggNOG; ENOG502RFWT; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q54U89; -.
DR OMA; YEYTQNC; -.
DR PhylomeDB; Q54U89; -.
DR PRO; PR:Q54U89; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:dictyBase.
DR GO; GO:0005542; F:folic acid binding; IDA:dictyBase.
DR GO; GO:0106063; F:G protein-coupled folate receptor activity; IDA:dictyBase.
DR GO; GO:0001530; F:lipopolysaccharide binding; IDA:dictyBase.
DR GO; GO:0043326; P:chemotaxis to folate; IMP:dictyBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:dictyBase.
DR GO; GO:0016045; P:detection of bacterium; IMP:dictyBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR GO; GO:0006911; P:phagocytosis, engulfment; IMP:dictyBase.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IMP:dictyBase.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IMP:dictyBase.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:dictyBase.
DR GO; GO:1905301; P:regulation of macropinocytosis; IMP:dictyBase.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..708
FT /note="Metabotropic glutamate receptor-like protein L"
FT /id="PRO_0000370355"
FT TOPO_DOM 25..370
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..435
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..568
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 569..589
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 590..597
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 619..708
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 638..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 366
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 708 AA; 78003 MW; C20804F00B331288 CRC64;
MKLIIKNLIL LLVSCLYFLS NVSCDQEVHM ALLLEGQVDD LGINYEVNQG LAETEALIQR
AAKVINDANS YDSTYDNIKS LLDQDNPYNL IITSSESQMS AALDIASDYE DTYFLIFGDM
GDKKVPHSKV GTYYFNLVSP HFVLGFIAGG MGKSVGMVVP GPPTENYFTA NAFYAGMKYY
TSPAGAPNPS LSVVATSSYD DYDTATGAGR ILLTKDIDIC TQSQTDMTVA NMFLNASKWA
FGTNGFPQSN IYGNRIIQSV VHNFQVPFYE AATMVMKNTW KNGYNFFGDF NNNFFYLDYY
SFLVDPLLKN QTEDLISTIK GGAKPYITNG LTYEKILEQT KLSTGITDLG YYAVPTTEVY
TTGSINKTFM AVSILEMAIC LIIGIIVIFF FSRNINIIYS TIPYCLTILL GASLIAVAIF
LWNLRDLNTQ ICTSKIWMAS LGYNVLIGFI IIKSSLIYFK FKEMVKSKNE KISPIPFGRI
VLWFVPLLII DCVLLIIYST SGNPGKIDSL GLDGIGRYEY TQNCVNNLTG DIILYIILVF
HGLQLLYGCV IAWKTRVIDL EEFIEAHDFA TAIYLITFCS FIIVILMVGV TSTSNRNTII
SACAIFSSFS CVLIIFGAKF WKIYKPVEDD GLPQIKLKPQ KSYSGSGGSG NSSGSKSKKT
SAHSSTSGVK SGTSAPTQTS QSAMASINIQ NFVNPIEASS RAAAQNDN
